人类胸腺上皮细胞信号分化因子表达的年龄相关差异。

Age-related differences in expression of signal differentiation factors for human thymic epithelial cells.

作者信息

Polyakova V O, Kvetnoy I M, Konovalov S S, Zezulin P N, Knyazkin I V

机构信息

St. Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences.

出版信息

Bull Exp Biol Med. 2007 Aug;144(2):235-7. doi: 10.1007/s10517-007-0298-1.

DOI:10.1007/s10517-007-0298-1

PMID:18399289

Abstract

Expression of transcription proteins PAX1, Hoxa3, and TLP regulating differentiation of thymic epithelial cells is detected in human thymus starting from gestation week 22 until the age of 95 years. Expression of transcription factors significantly decreased during aging. Apart from the decrease in the expression of signal differentiation factors in cultured thymic epithelial cells, proliferative activity of T lymphocytes cocultured with thymic epithelial cells also decreased in aging cultures, which demonstrated the important regulatory effect of transcription proteins on maturation and maintenance of T lymphocytes. Taking into account the important role of transcription proteins in the regulation of proliferation and function of T lymphocytes, whose number sharply decreases during aging, the maintenance of the level of expression of transcription factors during aging is a promising trend in modern biogerontology.

摘要

从妊娠第22周开始直至95岁，在人类胸腺中均可检测到调节胸腺上皮细胞分化的转录蛋白PAX1、Hoxa3和TLP的表达。衰老过程中转录因子的表达显著下降。除了培养的胸腺上皮细胞中信号分化因子的表达减少外，与胸腺上皮细胞共培养的T淋巴细胞的增殖活性在衰老培养物中也降低，这表明转录蛋白对T淋巴细胞的成熟和维持具有重要的调节作用。鉴于转录蛋白在调节T淋巴细胞增殖和功能方面的重要作用，而T淋巴细胞数量在衰老过程中急剧减少，因此在衰老过程中维持转录因子的表达水平是现代生物老年学中一个有前景的研究方向。