肽调节皮质胸腺细胞的分化、增殖和凋亡。

Khavinson V Kh, Polyakova V O, Linkova N S, Dudkov A V, Kvetnoy I M

Saint-Petersburg Institute of Bioregulation and Gerontology, RAMS pr. Dinamo 3, St. Petersburg 197110, Russia.

J Amino Acids. 2011;2011:517137. doi: 10.4061/2011/517137. Epub 2011 Nov 28.

The processes of differentiation, proliferation, and apoptosis were studied in a cell culture of human cortical thymocytes under the influence of short peptides T-32 (Glu-Asp-Ala) and T-38 (Lys-Glu-Asp). Peptides T-32 and T-38 amplified cortical thymocytes differentiation towards regulatory T cells, increased their proliferative activity, and decreased the level of apoptosis. Moreover, peptides under study stimulated proliferative and antiapoptotic activity of the mature regulatory T cells.

在短肽T-32（谷氨酸-天冬氨酸-丙氨酸）和T-38（赖氨酸-谷氨酸-天冬氨酸）的影响下，对人皮质胸腺细胞的细胞培养物中的分化、增殖和凋亡过程进行了研究。肽T-32和T-38增强了皮质胸腺细胞向调节性T细胞的分化，提高了它们的增殖活性，并降低了凋亡水平。此外，所研究的肽刺激了成熟调节性T细胞的增殖和抗凋亡活性。