CNP - 22刺激而非抑制大鼠饮水：C型利钠肽独特生物学作用的证据。

CNP-22 stimulates, rather than inhibits, water drinking in the rat: evidence for a unique biological action of the C-type natriuretic peptides.

作者信息

Samson W K, Skala K D, Huang F L

机构信息

Department of Anatomy and Neurobiology, University of Missouri School of Medicine, Columbia 65212.

出版信息

Brain Res. 1991 Dec 24;568(1-2):285-8. doi: 10.1016/0006-8993(91)91410-3.

DOI:10.1016/0006-8993(91)91410-3

PMID:1839968

Abstract

C-type natriuretic peptide (CNP) shares structural homology with A-type natriuretic peptide (ANP). Unlike ANP, which inhibits experimentally induced water drinking, CNP stimulates intake under similar conditions. The action of CNP to stimulate water drinking is not due to competition with ANP for the clearance receptor which recognizes both peptides since the ligand specific for that binding site, C-ANF 4-23, like ANP, inhibits water drinking under the same conditions.

摘要

C型利钠肽（CNP）与A型利钠肽（ANP）具有结构同源性。与抑制实验诱导饮水的ANP不同，CNP在类似条件下会刺激饮水。CNP刺激饮水的作用并非由于与ANP竞争识别这两种肽的清除受体，因为该结合位点的特异性配体C-ANF 4-23与ANP一样，在相同条件下会抑制饮水。