Itoh H, Nakao K, Yamada T, Shirakami G, Kangawa K, Minamino N, Matsuo H, Imura H
Department of Medicine, Kyoto University School of Medicine, Japan.
Eur J Pharmacol. 1988 May 20;150(1-2):193-6. doi: 10.1016/0014-2999(88)90769-8.
The effect of intracerebroventricular (i.c.v.) administration of brain natriuretic peptide (BNP) on water drinking was studied in rats. The i.c.v. injection of BNP at a dose of 1.5 nmol elicited no apparent change in spontaneous water intake in rats but significantly attenuated the water intake induced by the i.c.v. administration of 0.1 nmol of angiotensin II. The antidipsogenic action of BNP was comparable to that of atrial natriuretic polypeptide (ANP). These findings suggest that BNP could play a role in the regulation of water intake in the central nervous system, either alone or in concert with brain ANP.
研究了脑室内（i.c.v.）注射脑钠肽（BNP）对大鼠饮水的影响。以1.5 nmol的剂量脑室内注射BNP未引起大鼠自发饮水量的明显变化，但显著减弱了由脑室内注射0.1 nmol血管紧张素II诱导的饮水量。BNP的抗饮水作用与心钠素（ANP）相当。这些发现表明，BNP可能在中枢神经系统的饮水调节中发挥作用，无论是单独作用还是与脑ANP协同作用。
