Murray Kristy O, Baraniuk S, Resnick M, Arafat R, Kilborn C, Shallenberger R, York T L, Martinez D, Malkoff M, Elgawley N, McNeely W, Khuwaja S A
Center for Infectious Diseases, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Vector Borne Zoonotic Dis. 2008 Apr;8(2):167-74. doi: 10.1089/vbz.2007.0109.
The objective of this study was to describe the clinical features of cases hospitalized with West Nile virus (WNV) infections and identify clinical parameters that could potentially predict poor outcome (death). Retrospective medical chart reviews were completed for 172 confirmed cases of WNV infection hospitalized in the Houston, Texas, metropolitan area between 2002 and 2004. Of the 172 patients, 113 had encephalitis which resulted in 17 deaths, 47 had meningitis, and 12 had uncomplicated fever. Risk factors associated with progression from encephalitis to death were absence of pleocytosis in the cerebrospinal fluid, renal insufficiency, requiring intubation and mechanical ventilation, presence of myoclonus or tremors, and loss of consciousness. These findings can aid physicians in evaluating their patients suspected of WNV infection and determining outcomes in their patients with confirmed WNV neuroinvasive disease.
本研究的目的是描述因西尼罗河病毒（WNV）感染而住院的病例的临床特征，并确定可能预测不良结局（死亡）的临床参数。对2002年至2004年期间在得克萨斯州休斯敦大都市地区住院的172例确诊WNV感染病例进行了回顾性病历审查。在这172例患者中，113例患有脑炎，导致17例死亡，47例患有脑膜炎，12例有单纯发热。与从脑炎进展到死亡相关的危险因素包括脑脊液中无细胞增多、肾功能不全、需要插管和机械通气、存在肌阵挛或震颤以及意识丧失。这些发现有助于医生评估疑似WNV感染的患者，并确定确诊WNV神经侵袭性疾病患者的预后。
