肺康复对特发性肺纤维化患者的影响。

Effects of pulmonary rehabilitation in patients with idiopathic pulmonary fibrosis.

作者信息

Nishiyama Osamu, Kondoh Yasuhiro, Kimura Tomoki, Kato Keisuke, Kataoka Kensuke, Ogawa Tomoya, Watanabe Fumiko, Arizono Shinichi, Nishimura Koichi, Taniguchi Hiroyuki

机构信息

Department of Respiratory Medicine and Allergy, Tosei General Hospital, Seto Aichi, Japan.

出版信息

Respirology. 2008 May;13(3):394-9. doi: 10.1111/j.1440-1843.2007.01205.x.

DOI:10.1111/j.1440-1843.2007.01205.x

PMID:18399862

Abstract

BACKGROUND AND OBJECTIVE

Although pulmonary rehabilitation is effective for patients with COPD, its efficacy in patients with IPF is unknown. The purpose of this study was to evaluate the effects of pulmonary rehabilitation in IPF.

METHODS

Thirty patients diagnosed with IPF, according to the consensus statement, were randomly assigned to the rehabilitation group or the control group. The pulmonary rehabilitation mainly consisted of a 10-week programme of exercise training. Pulmonary function, blood gas analysis, 6MWD, dyspnoea rating with the baseline dyspnoea index and health-related quality of life score on the St George's Respiratory Questionnaire were evaluated at baseline and after the programme.

RESULTS

Assessment of efficacy was carried out on 13 patients who completed the programme and 15 patients in the control group. There were no significant effects of the programme on measures of pulmonary function, values of arterial blood gas analysis or dyspnoea rating. Although there were some differences in the baseline 6MWD and total health-related quality of life score which were not statistically significant, marked improvements were observed in the 6MWD (mean difference 46.3 m (95% CI: 8.3-84.4), P < 0.05) and the total health-related quality of life score (-6.1 (95% CI: -11.7 to -0.5), P < 0.05).

CONCLUSIONS

Pulmonary rehabilitation improves both exercise capacity and health-related quality of life in patients with IPF.

摘要

背景与目的

尽管肺康复对慢性阻塞性肺疾病（COPD）患者有效，但其对特发性肺纤维化（IPF）患者的疗效尚不清楚。本研究的目的是评估肺康复对IPF患者的影响。

方法

根据共识声明，30例诊断为IPF的患者被随机分配至康复组或对照组。肺康复主要包括为期10周的运动训练计划。在基线期和计划结束后，评估肺功能、血气分析、6分钟步行距离（6MWD）、采用基线呼吸困难指数的呼吸困难评分以及圣乔治呼吸问卷中与健康相关的生活质量评分。

结果

对13例完成该计划的患者和15例对照组患者进行了疗效评估。该计划对肺功能指标、动脉血气分析值或呼吸困难评分均无显著影响。尽管基线期6MWD和与健康相关的生活质量总分存在一些差异，但差异无统计学意义，然而6MWD（平均差值46.3 m（95%可信区间：8.3 - 84.4），P < 0.05）和与健康相关的生活质量总分（-6.1（95%可信区间：-11.7至-0.5），P < 0.05）均有显著改善。