反复接触甲基苯丙胺会导致持久的突触前皮质纹状体抑制，而再次给药可使其恢复正常。
Repeated exposure to methamphetamine causes long-lasting presynaptic corticostriatal depression that is renormalized with drug readministration.
作者信息
Bamford Nigel S, Zhang Hui, Joyce John A, Scarlis Christine A, Hanan Whitney, Wu Nan-Ping, André Véronique M, Cohen Rachel, Cepeda Carlos, Levine Michael S, Harleton Erin, Sulzer David
机构信息
Department of Neurology, University of Washington, Seattle, WA 98105, USA.
出版信息
Neuron. 2008 Apr 10;58(1):89-103. doi: 10.1016/j.neuron.2008.01.033.
Abstract
Addiction-associated behaviors such as drug craving and relapse are hypothesized to result from synaptic changes that persist long after withdrawal and are renormalized by drug reinstatement, although such chronic synaptic effects have not been identified. We report that exposure to the dopamine releaser methamphetamine for 10 days elicits a long-lasting (>4 month) depression at corticostriatal terminals that is reversed by methamphetamine readministration. Both methamphetamine-induced chronic presynaptic depression and the drug's selective renormalization in drug-experienced animals are independent of corresponding long-term changes in synaptic dopamine release but are due to alterations in D1 dopamine and cholinergic receptor systems. These mechanisms might provide a synaptic basis that underlies addiction and habit learning and their long-term maintenance.
摘要
成瘾相关行为，如药物渴望和复发，被认为是由戒断后长期持续的突触变化引起的，并且通过药物复吸可使其恢复正常，尽管尚未确定这种慢性突触效应。我们报告，暴露于多巴胺释放剂甲基苯丙胺10天会在皮质纹状体终末引发持久（>4个月）的抑制，而甲基苯丙胺再次给药可使其逆转。甲基苯丙胺诱导的慢性突触前抑制以及该药物在有药物使用经历的动物中的选择性恢复正常，均与突触多巴胺释放的相应长期变化无关，而是由于D1多巴胺和胆碱能受体系统的改变所致。这些机制可能为成瘾、习惯学习及其长期维持提供突触基础。
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本文引用的文献
1
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Nature. 2006 Aug 31;442(7106):1042-5. doi: 10.1038/nature05051. Epub 2006 Aug 23.
2
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3
Selective disruption of nucleus accumbens gating mechanisms in rats behaviorally sensitized to methamphetamine.对甲基苯丙胺行为致敏大鼠伏隔核门控机制的选择性破坏
J Neurosci. 2005 Jul 13;25(28):6687-95. doi: 10.1523/JNEUROSCI.0643-05.2005.
4
Mechanisms of neurotransmitter release by amphetamines: a review.安非他明释放神经递质的机制：综述
Prog Neurobiol. 2005 Apr;75(6):406-33. doi: 10.1016/j.pneurobio.2005.04.003.
5
Up-regulation of beta2 and alpha7 subunit containing nicotinic acetylcholine receptors in mouse striatum at cellular level.小鼠纹状体中含β2和α7亚基的烟碱型乙酰胆碱受体在细胞水平上的上调。
Eur J Neurosci. 2005 May;21(10):2681-91. doi: 10.1111/j.1460-9568.2005.04105.x.
6
Desensitized nicotinic receptors in brain.大脑中脱敏的烟碱型受体。
Brain Res Brain Res Rev. 2005 Jun;48(3):420-37. doi: 10.1016/j.brainresrev.2004.09.003.
7
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Psychopharmacology (Berl). 2005 Jul;180(3):473-90. doi: 10.1007/s00213-005-2180-z. Epub 2005 Feb 25.
8
Acute and chronic continuous methamphetamine have different long-term behavioral and neurochemical consequences.急性和慢性持续使用甲基苯丙胺会产生不同的长期行为和神经化学后果。
Neurochem Int. 2005 Feb;46(3):189-203. doi: 10.1016/j.neuint.2004.11.004. Epub 2005 Jan 8.
9
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J Neurosci. 2004 Dec 15;24(50):11328-36. doi: 10.1523/JNEUROSCI.1559-04.2004.
10
Addiction as a computational process gone awry.成瘾是一个出了差错的计算过程。
Science. 2004 Dec 10;306(5703):1944-7. doi: 10.1126/science.1102384.
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