Fourcaudot Elodie, Gambino Frederic, Casassus Guillaume, Poulain Bernard, Humeau Yann, Lüthi Andreas
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Nat Neurosci. 2009 Sep;12(9):1093-5. doi: 10.1038/nn.2378. Epub 2009 Aug 2.
The molecular mechanisms underlying the expression of postsynaptic long-term potentiation (LTP) at glutamatergic synapses are well understood. However, little is known about those that mediate the expression of presynaptic LTP. We found that presynaptic LTP at cortical inputs to the mouse lateral amygdala was blocked and reversed by L-type voltage-dependent Ca(2+) channel (L-VDCC) blockers. Thus, a persistent increase in L-VDCC-mediated glutamate release underlies the expression of presynaptic LTP in the amygdala.
谷氨酸能突触后长时程增强（LTP）表达的分子机制已得到充分理解。然而，对于介导突触前LTP表达的机制却知之甚少。我们发现，小鼠外侧杏仁核皮质输入处的突触前LTP被L型电压依赖性钙通道（L-VDCC）阻滞剂阻断并逆转。因此，L-VDCC介导的谷氨酸释放持续增加是杏仁核中突触前LTP表达的基础。
