Sakamoto A, Sugano H
Gan. 1976 Apr;67(2):263-73.
A clinico-pathological study of 20 cases of mixed mesodermal tumor of the uterine body is reported. Fifteen tumors were found after menopause. The mean age of all cases was 55.5 years. Histologically, mixed mesodermal tumors consisted of two different components; epithelial and sarcomatous patterns, in 18 cases. Mixed mesodermal tumors in four of the 18 cases had no adenocarcinomatous elements but showed a benign glandular structure. In the remaining two tumors, epithelial patterns were absent and only heterologous sarcomatous elements were found. Ten of the patients had received hysterectomy more than five years ago. Three of these patients, having no malignant but benign epithelial component, showed a relatively good prognosis. Adenocarcinomatous elements were found in six cases, and four patients with carcinomatous elements had poor prognosis. It can be stated that the prognosis of mixed mesodermal tumor chiefly depends on the malignancy of epithelial components, when comparing the prognosis of the tumors at the same clinical stage. On the other hand, sarcomatous elements are not likely to reflect the prognosis of the tumors. Mixed mesodermal tumor is monodermal in origin, namely, mesodermal origin, and might arise from the Muellerian duct or more primitive mesodermal tissue.
本文报告了20例子宫体混合性中胚叶肿瘤的临床病理研究。15例肿瘤在绝经后发现。所有病例的平均年龄为55.5岁。组织学上，18例混合性中胚叶肿瘤由两种不同成分组成，即上皮和肉瘤样结构。18例中的4例混合性中胚叶肿瘤无腺癌成分，但显示良性腺结构。其余2例肿瘤无上皮结构，仅发现异源性肉瘤成分。10例患者在5年多前接受了子宫切除术。其中3例患者无恶性但有良性上皮成分，预后相对较好。6例发现腺癌成分，4例有癌成分的患者预后较差。可以说，在比较相同临床分期肿瘤的预后时，混合性中胚叶肿瘤的预后主要取决于上皮成分的恶性程度。另一方面，肉瘤成分不太可能反映肿瘤的预后。混合性中胚叶肿瘤起源于单胚层，即中胚层起源，可能起源于苗勒管或更原始的中胚层组织。
