Türk Uğur, Alioğlu Emin, Tengiz Istemihan, Ercan Ertuğrul, Mahmudov Reşat, Duygu Hamza, Türkoğlu Cüneyt
Department of Cardiology, Central Hospital, Izmir, Turkey.
Anadolu Kardiyol Derg. 2008 Apr;8(2):99-103.
Atherosclerosis is a chronic inflammatory disease. Statins suppress the inflammation in the plaque. This cross-sectional study was planned to evaluate the effect of statins on plaque T cell activation markers in patients with stable angina pectoris undergoing coronary intervention and atherectomy procedures.
Twenty-six patients with stable angina with suitable for atherectomy coronary lesions were enrolled in the study. Fourteen of 26 patients who had been taking statin treatment for at least six months were assigned to the Group 1 (Statin group) and 12 patients who had not received any lipid lowering treatment comprised the Group 2 (Control group). Atherectomy specimens were studied with single and double immunohistochemical staining (CD25, CD69, and CD40L). Statistical analysis was performed using Student's t-test and Fisher's exact test.
There was no significant difference between the total tissue area of sections (Group 1: 8.4+/-0.9 mm2, Group 2: 7.8+/-0.9 mm2, p>0.05). CD3, CD25, CD69, and CD40L positive cells did not show statistically significant difference between the groups in unit area (mm2). There was no significant difference between the groups for percentage of T lymphocytes expressing CD25 (Group 1: 7.8+/-4.6%, Group 2: 7.8+/-5.9%, p=0.97) and CD 69 (Group 1: 12.9+/-4.6%, Group 2: 15.5+/-5.2%, p=0.203). The expression of CD40L was significantly lower in Group 1 than in Group 2 (Group 1: 4.8+/-3.9%, Group 2: 11.2+/-8.7%, p=0.034).
We concluded that, statin treatment may decrease the expression of CD40L on plaque T lymphocytes in patients with stable angina pectoris.
动脉粥样硬化是一种慢性炎症性疾病。他汀类药物可抑制斑块内的炎症。本横断面研究旨在评估他汀类药物对接受冠状动脉介入治疗和动脉粥样硬化斑块切除术的稳定型心绞痛患者斑块T细胞活化标志物的影响。
26例患有适合进行斑块切除术的冠状动脉病变的稳定型心绞痛患者纳入本研究。26例患者中，14例服用他汀类药物至少6个月，被分配到第1组（他汀类药物组）；12例未接受任何降脂治疗的患者组成第2组（对照组）。采用单重和双重免疫组织化学染色（CD25、CD69和CD40L）对斑块切除术标本进行研究。使用学生t检验和Fisher精确检验进行统计分析。
切片的总组织面积在两组之间无显著差异（第1组：8.4±0.9mm²，第2组：7.8±0.9mm²，p>0.05）。单位面积（mm²）内，CD3、CD25、CD69和CD40L阳性细胞在两组之间无统计学显著差异。表达CD25的T淋巴细胞百分比（第1组：7.8±4.6%，第2组：7.8±5.9%，p = 0.97）和CD69（第1组：12.9±4.6%，第2组：15.5±5.2%，p = 0.203）在两组之间无显著差异。第1组中CD40L的表达显著低于第2组（第1组：4.8±3.9%，第2组：11.2±8.7%，p = 0.034）。
我们得出结论，他汀类药物治疗可能会降低稳定型心绞痛患者斑块T淋巴细胞上CD40L的表达。
