单肾大鼠摄入N-4-(4'-氟联苯)乙酰胺后对肝癌易感性增加。
Increased susceptibility to carcinoma of the liver in rats with one kidney ingesting N-4-(4'-fluorobiphenyl) acetamide.
作者信息
Reuber M D
出版信息
Gan. 1976 Apr;67(2):307-11.
The role of the kidneys in hepatic carcinogenesis was studied in inbred Buffalo strain male rats ingesting 0.04% N-4-(4'-flourobiphenyl) acetamide in the diet. Experimental groups were made up of male rats with both kidneys intact and male rats with the left kidney removed. The incidence of carcinomas of the liver and the number of rats with large carcinomas, multiple carcinomas, poorly differentiated and undifferentiated carcinomas, and metastases were greater in rats with a uninephrectomy. Apparently the animals with one kidney removed were unable to secrete the metabolites of N-4-(4'-fluorobiphenyl) acetamide as readily as the rats with both kidneys.
在以含0.04% N-4-(4'-氟联苯)乙酰胺的饲料喂养的近交布法罗品系雄性大鼠中，研究了肾脏在肝癌发生中的作用。实验组由双侧肾脏完整的雄性大鼠和左肾切除的雄性大鼠组成。在单侧肾切除的大鼠中，肝癌的发生率以及患有大癌、多发癌、低分化和未分化癌及转移瘤的大鼠数量更多。显然，单侧肾切除的动物不能像双侧肾脏的大鼠那样轻易地分泌N-4-(4'-氟联苯)乙酰胺的代谢产物。
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