Boutin J P, Spiegel A, Flye Sainte-Marie F, Cartel J L, Girard M, Saliou P, Roux J
Institut de Médecine Tropicale du Service de Santé des Armées, Marseille.
Bull Soc Pathol Exot. 1991;84(5 Pt 5):906-11.
A seroepidemiological survey of hepatitis B was conducted in 1988 in the Austral archipelago (French Polynesia) in a randomly selected sample of 957 persons, has showed an infection rate (at least one positive marker) with HBV of 64.1% for the entire archipelago. Among women of child-bearing age, HBs Ag carriage rate was 11.45% of whom 19.1% were so HBe Ag carriers. Among infants HBs Ag carriage rate was 2.1% and among juveniles it was 10.6%. In this area horizontal transmission of HBV is essential. An immunization program was implemented in August 1988 using a recombinant vaccine (GenHevac BTM). At one year of the program, 97% of the children had received at least one dose of vaccine, 90% had HBs-antibodies titer higher than 10 mUI/ml, 96% had seroconverted for at least one of the two antibodies (anti-HBs and/or anti-preS2) and any of them was neither HBs Ag carrier nor anti-HBc IgM antibodies carrier. Finally, among 7 neonates whose mother were positive for both HBs Ag and HBe Ag, 6 were immunes and the last one, aged of 1 month (one dose received only), was not HBs Ag carrier. These preliminary results show that vaccination with GenHevac BTM to be immunogenic and effective in field conditions.
1988年在南太平洋群岛（法属波利尼西亚）对957人进行了随机抽样的乙肝血清流行病学调查，结果显示整个群岛乙肝病毒（HBV）感染率（至少一项阳性指标）为64.1%。育龄妇女中，乙肝表面抗原（HBs Ag）携带率为11.45%，其中e抗原（HBe Ag）携带者占19.1%。婴儿中HBs Ag携带率为2.1%，青少年中为10.6%。在该地区，HBV的水平传播至关重要。1988年8月实施了一项免疫计划，使用重组疫苗（GenHevac BTM）。在该计划实施一年时，97%的儿童至少接种了一剂疫苗，90%的儿童乙肝表面抗体滴度高于10 mUI/ml，96%的儿童至少对两种抗体（抗-HBs和/或抗-preS2）中的一种发生了血清转化，且无一例是HBs Ag携带者或抗-HBc IgM抗体携带者。最后，在7名母亲HBs Ag和HBe Ag均呈阳性的新生儿中，6名具有免疫力（已获免疫），最后一名1个月大的婴儿（仅接种了一剂疫苗）不是HBs Ag携带者。这些初步结果表明，GenHevac BTM疫苗在现场条件下具有免疫原性且有效。
