Kuwano Ryoichi, Kusano Hiroki
Department of Chemistry, Graduate School of Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
Org Lett. 2008 May 15;10(10):1979-82. doi: 10.1021/ol800548t. Epub 2008 Apr 11.
Benzyl protection of phenols under neutral conditions was achieved by using a Pd(eta3-C3H5)Cp-DPEphos catalyst. The palladium catalyst efficiently converted aryl benzyl carbonates into benzyl-protected phenols through the decarboxylative etherification. Alternatively, the nucleophilic substitution of benzyl methyl carbonates with phenols proceeded in the presence of the catalyst, yielding aryl benzyl ethers.
在中性条件下，通过使用钯（η3 - 环丙基）环戊二烯 - 二（二苯基膦）乙烷（Pd(η3-C3H5)Cp-DPEphos）催化剂实现了酚类的苄基保护。钯催化剂通过脱羧醚化反应有效地将芳基苄基碳酸酯转化为苄基保护的酚类。另外，在该催化剂存在下，苄基甲基碳酸酯与酚类发生亲核取代反应，生成芳基苄基醚。
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