钯催化的唑与碳酸苄酯的直接苄基化反应。
Palladium-catalyzed direct benzylation of azoles with benzyl carbonates.
机构信息
Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
出版信息
Org Lett. 2010 Mar 19;12(6):1360-3. doi: 10.1021/ol1002576.
PMID:20180547
Abstract
The direct aromatic sp(2) C-H benzylation of azole compounds with benzyl carbonates proceeds efficiently in the presence of a Pd(2)(dba)(3)/dppp catalyst system and NaOAc as a base to afford the corresponding diarylmethanes in good yields. In addition, the same palladium catalyst enables the direct benzylic sp(3) C-H benzylation with the second benzyl carbonates without employing any external base.
摘要
在 Pd(2)(dba)(3)/dppp 催化剂体系和作为碱的 NaOAc 的存在下，唑类化合物与碳酸苄酯的直接芳基 sp(2)C-H 苄基化反应高效进行，以良好的收率得到相应的二芳基甲烷。此外，相同的钯催化剂能够在不使用任何外部碱的情况下，用第二种碳酸苄酯进行直接苄基 sp(3)C-H 苄基化。
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