Meola Juliana, Dentillo Daniel Blassioli, Rosa e Silva Júlio César, Ferriani Rui Alberto, Veiga Luciana Caricati, Paro de Paz Cláudia Cristina, Giuliatti Silvana, Martelli Lúcia
Department of Genetics, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Fertil Steril. 2009 May;91(5):1676-80. doi: 10.1016/j.fertnstert.2008.02.158. Epub 2008 Apr 9.
To analyze the expression of the glycodelin gene to better understand the molecular environment of endometriotic lesions and to elucidate the potential mechanisms that underlie the complex physiopathology of endometriosis.
Prospective laboratory study.
University hospital.
PATIENT(S): Eleven healthy fertile women and 17 patients with endometriosis in the early proliferative phase of the menstrual cycle.
INTERVENTION(S): Endometrial biopsy specimens were obtained from the endometrium of healthy women without endometriosis (controls) and from eutopic and ectopic endometrium tissues (pelvic and ovarian endometriotic implants) of endometriosis patients.
MAIN OUTCOME MEASURE(S): The glycodelin relative expression level by real-time polymerase chain reaction (PCR) analysis.
RESULT(S): The glycodelin down-regulation found in the endometriotic lesions was 332.26 and 123.17-fold lower, respectively, when compared with the eutopic tissue and the control endometrium.
CONCLUSION(S): Glycodelin may be one of the molecules that contributes to the loss of cellular homeostasis in endometriotic lesions.
分析糖蛋白140基因的表达，以更好地了解子宫内膜异位症病灶的分子环境，并阐明子宫内膜异位症复杂病理生理学背后的潜在机制。
前瞻性实验室研究。
大学医院。
11名健康可育女性以及17名处于月经周期早期增殖期的子宫内膜异位症患者。
从无子宫内膜异位症的健康女性（对照组）的子宫内膜以及子宫内膜异位症患者的在位内膜和异位内膜组织（盆腔和卵巢子宫内膜异位种植体）获取子宫内膜活检标本。
通过实时聚合酶链反应（PCR）分析糖蛋白140的相对表达水平。
与在位组织和对照子宫内膜相比，子宫内膜异位症病灶中糖蛋白140的下调分别低332.26倍和123.17倍。
糖蛋白140可能是导致子宫内膜异位症病灶细胞内环境稳定丧失的分子之一。
