Ortega M, Juan M C, Alcañiz M, Gil J A, Monserrat C
LabHuman (formerly MedICLab), Technical University of Valencia, Spain.
Comput Med Imaging Graph. 2008 Jul;32(5):367-78. doi: 10.1016/j.compmedimag.2008.02.003. Epub 2008 Apr 9.
Parkinson's disease is a degenerative disease of the central nervous system. One of the most effective treatments is deep brain stimulation. This technique requires the localization of an objective structure: the subthalamic nucleus. Unfortunately this structure is difficult to locate. In this work the creation of a deformable brain atlas that enables the identification of the subthalamic nucleus in T1-weighted magnetic resonance imaging (MRI) in an automatic, precise and fast way is presented. The system has been validated using data from 10 patients (20 nucleus) operated on for Parkinson's. Our system offers better results using a Wendland function with an error of 1.8853+/-0.9959mm.
帕金森病是一种中枢神经系统退行性疾病。最有效的治疗方法之一是深部脑刺激。该技术需要定位一个目标结构：丘脑底核。不幸的是，这个结构很难定位。在这项工作中，提出了一种可变形脑图谱的创建方法，该方法能够以自动、精确和快速的方式在T1加权磁共振成像（MRI）中识别丘脑底核。该系统已使用10名接受帕金森病手术患者（20个核）的数据进行了验证。我们的系统使用温德兰函数提供了更好的结果，误差为1.8853±0.9959毫米。
