Valentine B A, Cooper B J
Department of Pathology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853-6401.
Neuromuscul Disord. 1991;1(1):31-8. doi: 10.1016/0960-8966(91)90040-y.
The development of lesions in dogs with canine X-linked muscular dystrophy (CXMD) was studied in dogs from birth to 8 weeks of age. Selective involvement of muscles was noted in dogs up to 4 weeks of age, after which lesions were noted in all muscles examined. Marked fiber hypertrophy was a consequence of the dystrophic process. Severe degenerative lesions were first detected in the tongue, diaphragm, trapezius, deltoideus, extensor carpi radialis, sartorius, and cranial tibial muscles, with relative sparing of the triceps, biceps femoris, and quadriceps muscles. Fiber necrosis and regeneration were present in the tongue muscle at birth, indicating onset of degeneration in utero. The propensity for early development of lesions in certain muscles could not be attributed to larger fiber diameter or to fiber maturity. It is suggested that early development of lesions in these muscles may be related to the activity of these muscles in neonatal dogs.
对患有犬X连锁肌营养不良（CXMD）的犬从出生到8周龄的病变发展情况进行了研究。在4周龄以下的犬中观察到肌肉的选择性受累，4周龄后在所有检查的肌肉中均发现病变。明显的纤维肥大是营养不良过程的结果。严重的退行性病变首先在舌肌、膈肌、斜方肌、三角肌、桡侧腕伸肌、缝匠肌和胫骨前肌中检测到，肱三头肌、股二头肌和股四头肌相对未受影响。出生时舌肌中存在纤维坏死和再生，表明子宫内就已开始退化。某些肌肉中病变的早期发展倾向不能归因于更大的纤维直径或纤维成熟度。有人认为，这些肌肉中病变的早期发展可能与新生犬这些肌肉的活动有关。
