Chiriac L M, Biro L, Vărgulescu D, Onofrei T, Fogel M E
Secţia de neurologie, Spitalul judeţean Bacău.
Rev Med Chir Soc Med Nat Iasi. 1991 Jan-Jun;95(1-2):59-61.
Based on muscle biopsies from 3 patients with stage II myasthenia gravis, the morphological alterations of the neuromuscular junction and the enzymatic disorders in the muscle fibres are studied. Abnormalities in the structure of nerve-endings (tumescence, irregularities and elongations of the fibres), more collaterals for the axon and motor plate, lymphocytic infiltrates, presence of antibodies for striated muscle fibre, rendered evident by immunofluorescence, were found. The enzymatic alterations (ATP-ase, succinyl dehydrogenase) induce a disturbance in the muscular energy metabolism.
基于3例II期重症肌无力患者的肌肉活检，研究了神经肌肉接头的形态学改变以及肌纤维中的酶紊乱情况。发现神经末梢结构异常（纤维肿胀、不规则和伸长）、轴突和运动终板有更多侧支、淋巴细胞浸润、免疫荧光显示存在针对横纹肌纤维的抗体。酶改变（ATP酶、琥珀酸脱氢酶）导致肌肉能量代谢紊乱。
