Senthilkumar Natesan, Badami Shrishailappa, Dongre Santoshkumar H, Bhojraj Suresh
Department of Pharmaceutical Chemistry, J. S. S. College of Pharmacy, Rock lands, Ootacamund, Tamil Nadu, 643 001, India.
J Nat Med. 2008 Jul;62(3):336-9. doi: 10.1007/s11418-008-0237-0. Epub 2008 Mar 20.
The methanol extract of Careya arborea bark (MECA) was tested for antioxidant and hepatoprotective activity in Ehrlich ascites carcinoma (EAC) tumor-bearing mice. Tumor control animals inoculated with EAC showed a significant alteration in the levels of antioxidant and hepatoprotective parameters. The extract treatment at 50, 100 and 200 mg/kg body weight doses given orally caused a significant reversal of these biochemical changes towards the normal in serum, liver and kidney when compared to tumor control animals indicating the potent antioxidant and hepatoprotective nature of the standardized extract.
对柯库树树皮的甲醇提取物（MECA）在艾氏腹水癌（EAC）荷瘤小鼠中进行了抗氧化和肝保护活性测试。接种EAC的肿瘤对照动物在抗氧化和肝保护参数水平上出现了显著变化。与肿瘤对照动物相比，口服给予50、100和200mg/kg体重剂量的提取物治疗后，血清、肝脏和肾脏中的这些生化变化显著逆转至正常水平，表明标准化提取物具有强大的抗氧化和肝保护特性。
