来自羯布罗香的低聚芪类化合物及其对P-388细胞的细胞毒性
Oligostilbenoids from Shorea gibbosa and their cytotoxic properties against P-388 cells.
作者信息
Saroyobudiono Haryoto, Juliawaty Lia D, Syah Yana M, Achmad Sjamsul A, Hakim Euis H, Latip Jalifah, Said Ikram M
机构信息
Natural Products Research Group, Department of Chemistry, Bandung Institute of Technology, Jalan Ganeca 10, Bandung, 40132, Indonesia.
出版信息
J Nat Med. 2008 Apr;62(2):195-8. doi: 10.1007/s11418-007-0205-0. Epub 2007 Nov 22.
A new oligostilbenoid derivative, diptoindonesin F (1), along with five known oligostilbenoids, (-)-ampelopsin A (2), (-)-alpha-viniferin (3), ampelopsin E (4), (-)-vaticanol B (5), and (-)-hemsleyanol D (6), were isolated from the methanol extract of the tree bark of Shorea gibbosa. The structure of the new compound was determined based on the analysis of spectroscopic data, including UV, IR, NMR 1-D and 2-D, and mass spectra. Cytotoxic properties of the isolated oligostilbenoids were evaluated against murine leukemia P-388 cells with the result that compounds 2 and 4 showed the highest cytotoxicity.
从冰片娑罗双树皮的甲醇提取物中分离出一种新的低聚芪类衍生物——二萜吲哚宁F（1），以及五种已知的低聚芪类化合物，即（-）-蛇葡萄素A（2）、（-）-α-葡萄素（3）、蛇葡萄素E（4）、（-）-龙脑香醇B（5）和（-）-滇葡萄素D（6）。通过对紫外、红外、一维和二维核磁共振以及质谱等光谱数据的分析确定了新化合物的结构。对分离得到的低聚芪类化合物针对小鼠白血病P-388细胞的细胞毒性进行了评估，结果显示化合物2和4具有最高的细胞毒性。
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