来自哈氏龙脑香树皮的细胞毒性白藜芦醇低聚物。

Cytotoxic resveratrol oligomers from the tree bark of Dipterocarpus hasseltii.

作者信息

Hakim Euis H, Juliawaty Lia D, Syah Yana M, Achmad Sjamsul A, Latip Jalifah, Ghisalberti Emilio L

机构信息

Department of Chemistry, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia.

出版信息

Fitoterapia. 2006 Dec;77(7-8):550-5. doi: 10.1016/j.fitote.2006.07.004. Epub 2006 Sep 22.

DOI:10.1016/j.fitote.2006.07.004

PMID:17071016

Abstract

A new resveratrol tetramer, named diptoindonesin E, was isolated from the acetone extract of the tree bark of Dipterocarpus hasseltii, together with five known resveratrol oligomers (-)-epsilon-viniferin, laevifonol, (-)-alpha-viniferin, vaticanol B, (-)-hopeaphenol, and a coumarin, scopoletin. The structures of these compounds were determined from spectroscopic evidence. Cytotoxicity test of the isolated compounds showed that hopeaphenol strongly inhibited murine leukemia P-388 cells.

摘要

从龙脑香科植物哈氏娑罗双树皮的丙酮提取物中分离出一种新的白藜芦醇四聚体，命名为二萜吲哚宁E，同时还分离出5种已知的白藜芦醇低聚物（-）-ε-葡萄素、左旋酚、（-）-α-葡萄素、紫檀醇B、（-）-霍佩酚以及一种香豆素东莨菪素。这些化合物的结构通过光谱证据得以确定。对分离出的化合物进行的细胞毒性测试表明，霍佩酚强烈抑制小鼠白血病P-388细胞。