羯布罗香树皮中低聚芪类化合物的细胞毒性特性
Cytotoxic properties of oligostilbenoids from the tree barks of Hopea dryobalanoides.
作者信息
Hakim Euis H, Juliawaty Lia D, Syah Yana M, bin Din Laily, Ghisalberti Emilio L, Latip Jalifah, Said Ikram M, Achmad Sjamsul A
机构信息
Department of Chemistry, Institut Teknologi Bandung, Indonesia.
出版信息
Z Naturforsch C J Biosci. 2005 Sep-Oct;60(9-10):723-7. doi: 10.1515/znc-2005-9-1011.
A new modified stilbene dimer, diptoindonesin D (1), was isolated from the acetone extract of the tree bark of Hopea dryobalanoides, together with seven known compounds, parviflorol (2), (-)-balanocarpol (3), heimiol A (4), hopeafuran (5), (+)-alpha-viniferin (6), vaticanol B (7) and (-)-hopeaphenol (8). Cytotoxic properties of compounds 1-8 were evaluated against murine leukemia P-388 cells. Compound 8 was found to be the most active with IC50 of 5.7 microM.
从望天树树皮的丙酮提取物中分离出一种新的修饰芪二聚体——二萜吲哚宁 D（1），以及七种已知化合物，小花酚（2）、（-）-巴豆果酚（3）、海米奥 A（4）、霍皮呋喃（5）、（+）-α-葡萄素（6）、瓦蒂卡诺醇 B（7）和（-）-霍皮酚（8）。评估了化合物 1 - 8 对小鼠白血病 P - 388 细胞的细胞毒性。发现化合物 8 活性最强，IC50 为 5.7 微摩尔。
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