Department of Clinical and Experimental Medicine, Pharmacology Section, University of Ferrara, Via Fossato di Mortara 17-19, 44100, Ferrara, Italy.
Purinergic Signal. 2006 Nov;2(4):627-32. doi: 10.1007/s11302-006-9020-4. Epub 2006 Jul 26.
Downstream A₃ receptor signalling plays an important role in the regulation of cell death and proliferation. Therefore, it is important to determine the molecular pathways involved through A₃ receptor stimulation. The phosphatidylinositide-3-OH kinase (PI3K)/Akt and the Raf/mitogen-activated protein kinase (MAPK/ERK) kinase (MEK)/mitogen-activated protein kinase (MAPK) pathways have central roles in the regulation of cell survival and proliferation. The crosstalk between these two pathways has also been investigated. The focus of this review centres on downstream mediators of A₃ adenosine receptor signalling.
下游 A₃ 受体信号在细胞死亡和增殖的调节中起着重要作用。因此，确定通过 A₃ 受体刺激涉及的分子途径非常重要。磷脂酰肌醇-3-OH 激酶 (PI3K)/Akt 和 Raf/丝裂原激活蛋白激酶 (MAPK/ERK) 激酶 (MEK)/丝裂原激活蛋白激酶 (MAPK) 途径在细胞存活和增殖的调节中起着核心作用。这两条途径之间的串扰也已被研究。本综述的重点是 A₃ 腺苷受体信号的下游介质。
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