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RKIP：肿瘤转移起始和抗凋亡的关键调节因子：治疗靶向与影响

RKIP: A Key Regulator in Tumor Metastasis Initiation and Resistance to Apoptosis: Therapeutic Targeting and Impact.

作者信息

Zaravinos Apostolos, Bonavida Benjamin, Chatzaki Ekaterini, Baritaki Stavroula

机构信息

Department of Life Sciences, School of Sciences, European University Cyprus, Nicosia 2404, Cyprus.

Centre for Risk and Decision Sciences (CERIDES), Nicosia 2404, Cyprus.

出版信息

Cancers (Basel). 2018 Aug 24;10(9):287. doi: 10.3390/cancers10090287.

DOI:10.3390/cancers10090287
PMID:30149591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6162400/
Abstract

RAF-kinase inhibitor protein (RKIP) is a well-established tumor suppressor that is frequently downregulated in a plethora of solid and hematological malignancies. RKIP exerts antimetastatic and pro-apoptotic properties in cancer cells, via modulation of signaling pathways and gene products involved in tumor survival and spread. Here we review the contribution of RKIP in the regulation of early metastatic steps such as epithelial⁻mesenchymal transition (EMT), migration, and invasion, as well as in tumor sensitivity to conventional therapeutics and immuno-mediated cytotoxicity. We further provide updated justification for targeting RKIP as a strategy to overcome tumor chemo/immuno-resistance and suppress metastasis, through the use of agents able to modulate RKIP expression in cancer cells.

摘要

RAF激酶抑制蛋白（RKIP）是一种公认的肿瘤抑制因子，在众多实体瘤和血液系统恶性肿瘤中常呈下调状态。RKIP通过调节参与肿瘤生存和扩散的信号通路及基因产物，在癌细胞中发挥抗转移和促凋亡特性。在此，我们综述了RKIP在调节早期转移步骤（如上皮-间质转化（EMT）、迁移和侵袭）中的作用，以及在肿瘤对传统疗法和免疫介导的细胞毒性的敏感性方面的作用。我们还通过使用能够调节癌细胞中RKIP表达的药物，进一步提供了以RKIP为靶点作为克服肿瘤化疗/免疫耐药性和抑制转移策略的最新依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2038/6162400/777f94190121/cancers-10-00287-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2038/6162400/251663a414b1/cancers-10-00287-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2038/6162400/884de1079d6a/cancers-10-00287-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2038/6162400/777f94190121/cancers-10-00287-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2038/6162400/251663a414b1/cancers-10-00287-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2038/6162400/884de1079d6a/cancers-10-00287-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2038/6162400/777f94190121/cancers-10-00287-g003.jpg

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