Department of Experimental and Diagnostic Medicine, Section of General Pathology and Interdisciplinary Center for the Study of Inflammation (ICSI), University of Ferrara, Ferrara, Italy.
Purinergic Signal. 2005 Sep;1(3):219-27. doi: 10.1007/s11302-005-6322-x. Epub 2005 Jul 29.
The P2X(7) plasma membrane receptor is an intriguing molecule that is endowed with the ability to kill cells, as well as to activate many responses and even stimulate proliferation. Here, the authors give an overview on the multiplicity and complexity of P2X(7)-mediated responses, discussing recent information on this receptor. Particular attention has been paid to early and late signs of apoptosis and necrosis linked to activation of the receptor and to the emerging field of P2X(7) function in carcinogenesis.
P2X(7) 等离子体膜受体是一种引人入胜的分子，它具有杀死细胞的能力，同时也能激活多种反应，甚至刺激增殖。在这里，作者概述了 P2X(7) 介导的反应的多样性和复杂性，讨论了有关该受体的最新信息。特别关注了与受体激活相关的细胞凋亡和坏死的早期和晚期迹象，以及 P2X(7) 在癌症发生中的作用这一新兴领域。
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