Richardson Brian, Beckett Karen, Baylies Mary
Program in Developmental Biology, Sloan Kettering Institute, USA.
Bioessays. 2008 May;30(5):423-31. doi: 10.1002/bies.20756.
Over several years, genetic studies in the model system, Drosophila melanogastor, have uncovered genes that when mutated, lead to a block in myoblast fusion. Analyses of these gene products have suggested that Arp2/3-mediated regulation of the actin cytoskeleton is crucial to myoblast fusion in the fly. Recent advances in imaging in Drosophila embryos, both in fixed and live preparations, have led to a new appreciation of both the three-dimensional organization of the somatic mesoderm and the cell biology underlying myoblast fusion.
在过去几年中，对模式生物黑腹果蝇的遗传学研究发现了一些基因，这些基因发生突变时会导致成肌细胞融合受阻。对这些基因产物的分析表明，Arp2/3介导的肌动蛋白细胞骨架调节对果蝇的成肌细胞融合至关重要。果蝇胚胎成像技术在固定标本和活体制备方面的最新进展，使人们对体壁中胚层的三维组织结构和成肌细胞融合背后的细胞生物学有了新的认识。
