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本文引用的文献

1
Regulation of the myoblast fusion reaction for muscle development, regeneration, and adaptations.肌肉发育、再生和适应过程中肌母细胞融合反应的调控。
Exp Cell Res. 2022 Jun 15;415(2):113134. doi: 10.1016/j.yexcr.2022.113134. Epub 2022 Mar 31.
2
Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein.动力蛋白作为一种多丝肌动蛋白结合蛋白,调节肌动球蛋白细胞骨架的动力学和机械强度。
Nat Cell Biol. 2020 Jun;22(6):674-688. doi: 10.1038/s41556-020-0519-7. Epub 2020 May 25.
3
Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects.系统分析表明WAVE2复合物与左心发育性梗阻性心脏缺陷的发病机制有关。
JACC Basic Transl Sci. 2020 Apr 8;5(4):376-386. doi: 10.1016/j.jacbts.2020.01.012. eCollection 2020 Apr.
4
Cell fusion is differentially regulated in zebrafish post-embryonic slow and fast muscle.细胞融合在斑马鱼胚胎后发育的慢肌和快肌中受到差异调控。
Dev Biol. 2020 Jun 1;462(1):85-100. doi: 10.1016/j.ydbio.2020.03.005. Epub 2020 Mar 10.
5
Myoblast Fusion: Invasion and Resistance for the Ultimate Union.成肌细胞融合:终极联合的入侵与抵抗。
Annu Rev Genet. 2019 Dec 3;53:67-91. doi: 10.1146/annurev-genet-120116-024603. Epub 2019 Jul 5.
6
The Developmental Phases of Zebrafish Myogenesis.斑马鱼肌肉生成的发育阶段
J Dev Biol. 2019 Jun 2;7(2):12. doi: 10.3390/jdb7020012.
7
How cells fuse.细胞如何融合。
J Cell Biol. 2019 May 6;218(5):1436-1451. doi: 10.1083/jcb.201901017. Epub 2019 Apr 1.
8
Genetic Mutations in jamb, jamc, and myomaker Revealed Different Roles on Myoblast Fusion and Muscle Growth.jamb、jamc 和 myomaker 中的基因突变揭示了它们在成肌细胞融合和肌肉生长中的不同作用。
Mar Biotechnol (NY). 2019 Feb;21(1):111-123. doi: 10.1007/s10126-018-9865-x. Epub 2018 Nov 22.
9
Myogenin promotes myocyte fusion to balance fibre number and size.肌生成蛋白促进肌细胞融合,以平衡纤维数量和大小。
Nat Commun. 2018 Oct 12;9(1):4232. doi: 10.1038/s41467-018-06583-6.
10
Spatiotemporal Coordination of FGF and Shh Signaling Underlies the Specification of Myoblasts in the Zebrafish Embryo.成肌细胞在斑马鱼胚胎中的特异性:FGF 和 Shh 信号时空协调的作用。
Dev Cell. 2018 Sep 24;46(6):735-750.e4. doi: 10.1016/j.devcel.2018.08.024.

斑马鱼融合突触的细胞结构和分子决定因素。

The cellular architecture and molecular determinants of the zebrafish fusogenic synapse.

机构信息

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

出版信息

Dev Cell. 2022 Jul 11;57(13):1582-1597.e6. doi: 10.1016/j.devcel.2022.05.016. Epub 2022 Jun 15.

DOI:10.1016/j.devcel.2022.05.016
PMID:35709765
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10180866/
Abstract

Myoblast fusion is an indispensable process in skeletal muscle development and regeneration. Studies in Drosophila led to the discovery of the asymmetric fusogenic synapse, in which one cell invades its fusion partner with actin-propelled membrane protrusions to promote fusion. However, the timing and sites of vertebrate myoblast fusion remain elusive. Here, we show that fusion between zebrafish fast muscle cells is mediated by an F-actin-enriched invasive structure. Two cell adhesion molecules, Jam2a and Jam3b, are associated with the actin structure, with Jam2a being the major organizer. The Arp2/3 actin nucleation-promoting factors, WAVE and WASP-but not the bipartite fusogenic proteins, Myomaker or Myomixer-promote the formation of the invasive structure. Moreover, the convergence of fusogen-containing microdomains and the invasive protrusions is a prerequisite for cell membrane fusion. Thus, our study provides unprecedented insights into the cellular architecture and molecular determinants of the asymmetric fusogenic synapse in an intact vertebrate animal.

摘要

成肌细胞融合是骨骼肌发育和再生过程中必不可少的。在果蝇中的研究导致了不对称融合突触的发现,其中一个细胞通过肌动蛋白驱动的膜突起侵入其融合伙伴以促进融合。然而,脊椎动物成肌细胞融合的时间和部位仍然难以捉摸。在这里,我们表明斑马鱼快肌细胞之间的融合是由富含 F-肌动蛋白的侵袭结构介导的。两个细胞粘附分子,Jam2a 和 Jam3b,与肌动蛋白结构相关,其中 Jam2a 是主要的组织者。Arp2/3 肌动蛋白成核促进因子 WAVE 和 WASP——而不是二聚体融合蛋白 Myomaker 或 Myomixer——促进侵袭结构的形成。此外,融合蛋白包含的微域和侵袭突起的收敛是细胞膜融合的前提。因此,我们的研究为完整的脊椎动物中不对称融合突触的细胞结构和分子决定因素提供了前所未有的见解。