远缘链球菌表面蛋白抗原基因的完整核苷酸序列。
Complete nucleotide sequence of the gene for a surface protein antigen of Streptococcus sobrinus.
作者信息
Tokuda M, Okahashi N, Takahashi I, Nakai M, Nagaoka S, Kawagoe M, Koga T
机构信息
Department of Dental Research, National Institute of Health, Tokyo, Japan.
出版信息
Infect Immun. 1991 Sep;59(9):3309-12. doi: 10.1128/iai.59.9.3309-3312.1991.
Abstract
The complete nucleotide sequence of the gene for a cell surface protein antigen (SpaA) of Streptococcus sobrinus MT3791 (serotype g) was determined. The spaA gene consisted of 4,698 bp and coded for a protein of 170,202 Da. A putative signal peptide was found in the amino-terminal end of the protein. A potential promoter sequence and a putative Shine-Dalgarno sequence preceded the open reading frame. Two internal repeating amino acid sequences were present in SpaA. One repeating region, located in the amino-terminal region, was rich in alanine, and the other, located in the central region, was rich in proline. The molecular structure of SpaA was very similar to that of the surface protein antigen of Streptococcus mutans.
摘要
测定了远缘链球菌MT3791（血清型g）细胞表面蛋白抗原（SpaA）基因的完整核苷酸序列。spaA基因由4698个碱基对组成，编码一种170202道尔顿的蛋白质。在该蛋白质的氨基末端发现了一个推定的信号肽。在开放阅读框之前有一个潜在的启动子序列和一个推定的Shine-Dalgarno序列。SpaA中存在两个内部重复氨基酸序列。一个重复区域位于氨基末端区域，富含丙氨酸，另一个位于中央区域，富含脯氨酸。SpaA的分子结构与变形链球菌表面蛋白抗原的结构非常相似。
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