Freudenberg Marina A, Tchaptchet Sandrine, Keck Simone, Fejer György, Huber Michael, Schütze Nicole, Beutler Bruce, Galanos Chris
Max-Planck-Institute for Immunobiology, Stübeweg 51, D-79108 Freiburg, Germany.
Immunobiology. 2008;213(3-4):193-203. doi: 10.1016/j.imbio.2007.11.008. Epub 2007 Dec 27.
In this review, we summarize our investigations concerning the differential importance of CD14 and LBP in toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2)-mediated signaling by smooth and rough-form lipopolysaccharide (LPS) chemotypes and include the results obtained in studies with murine and human TLR4-transgenic mice. Furthermore, we present more recent data on the mechanisms involved in the induction of LPS hypersensitivity by bacterial and viral infections and on the reactivity of the hypersensitive host to non-LPS microbial ligands and endogenous mediators. Finally, the effects of pre-existing hypersensitivity on the course and outcome of a super-infection with Salmonella typhimurium or Listeria monocytogenes are summarized.
在本综述中，我们总结了关于CD14和脂多糖结合蛋白（LBP）在Toll样受体4（TLR4）/髓样分化蛋白2（MD-2）介导的信号传导中，由光滑型和粗糙型脂多糖（LPS）化学型所发挥的不同重要性的研究，并纳入了在对小鼠和人TLR4转基因小鼠的研究中所获得的结果。此外，我们还展示了关于细菌和病毒感染诱导LPS超敏反应所涉及机制，以及超敏宿主对非LPS微生物配体和内源性介质反应性的最新数据。最后，总结了预先存在的超敏反应对鼠伤寒沙门氏菌或单核细胞增生李斯特菌二重感染病程及结果的影响。
