Covaci Adrian, Voorspoels Stefan, Roosens Laurence, Jacobs Werner, Blust Ronny, Neels Hugo
Toxicological Centre, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium.
Chemosphere. 2008 Sep;73(2):170-5. doi: 10.1016/j.chemosphere.2008.02.059. Epub 2008 Apr 11.
Levels of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) were measured in paired human adipose tissue and liver samples (n=25) from Belgium. Average concentrations and standard deviation of sum PBDEs (congeners 28, 47, 99, 100, 153, 154 and 183) were 5.3+/-3.0 (range 1.4-13.2) and 3.6+/-2.1 (range 1.0-10.0)ng g(-1) lipid weight (lw) in adipose tissue and liver, respectively. These concentrations were similar to reported PBDE data from Belgium and were at the lower end of the concentration range reported elsewhere in the world. In both tissues under study, BDE 153 and BDE 47 were the most abundant PBDE congeners, contributing approximately 35% and 25% to the total PBDE content. Average concentrations and range of PCBs (sum of 23 congeners) were 490 (range 70-1130) and 380 (range 90-1140)ng g(-1)lw in adipose tissue and liver, respectively. No correlation between age and concentrations of PBDEs could be found (r=0.04), while PCB concentrations correlated significantly with age (r=0.62, p<0.01, for the sum PCBs; r=0.64, p<0.01 for PCB 153 alone). Factors, such as exposure pathways (food, dust and air), rates of bioaccumulation, metabolism and elimination, influence the concentrations of PBDEs differently than those of PCBs in humans.
对来自比利时的25对人体脂肪组织和肝脏样本进行了多溴二苯醚(PBDEs)和多氯联苯(PCBs)含量的测定。脂肪组织和肝脏中PBDEs总和(同系物28、47、99、100、153、154和183)的平均浓度及标准差分别为5.3±3.0(范围1.4 - 13.2)和3.6±2.1(范围1.0 - 10.0)纳克/克脂质重量(lw)。这些浓度与比利时报告的PBDE数据相似,处于世界其他地区报告的浓度范围下限。在所研究的两种组织中,BDE 153和BDE 47是含量最高的PBDE同系物,分别占PBDE总含量的约35%和25%。脂肪组织和肝脏中PCBs(23种同系物总和)的平均浓度及范围分别为490(范围70 - 1130)和380(范围90 - 1140)纳克/克lw。未发现年龄与PBDEs浓度之间存在相关性(r = 0.04),而PCBs浓度与年龄显著相关(对于PCBs总和,r = 0.62,p < 0.01;对于单独的PCB 153,r = 0.64,p < 0.01)。诸如暴露途径(食物、灰尘和空气)、生物累积率、代谢和消除等因素,对人体中PBDEs浓度的影响与对PCBs浓度的影响不同。