用髓鞘碱性蛋白免疫的PLSJL小鼠小脑早期血脑屏障通透性
Early blood-brain barrier permeability in cerebella of PLSJL mice immunized with myelin basic protein.
作者信息
Spitsin Sergei, Portocarrero Carla, Phares Timothy W, Kean Rhonda B, Brimer Christine M, Koprowski Hilary, Hooper D Craig
机构信息
Thomas Jefferson University, 1020 Locust St., JAH room 470C, Philadelphia, PA 19107, United States.
出版信息
J Neuroimmunol. 2008 May 30;196(1-2):8-15. doi: 10.1016/j.jneuroim.2008.02.004. Epub 2008 Apr 11.
Abstract
The blood-brain barrier (BBB) is dramatically but transiently compromised in the cerebella of myelin basic protein immunized mice at least 1 week prior to the development of the paralytic phase of experimental allergic encephalomyelitis (EAE). Treatment of mice with the peroxynitrite-dependent radical scavenger uric acid (UA) during the first week after immunization blocks the early increase in cerebellar BBB permeability and the subsequent development of clinical signs of EAE. These results indicate that the early loss of BBB integrity in the cerebellum is likely to be a necessary step in the development of paralytic EAE.
摘要
在实验性变应性脑脊髓炎（EAE）麻痹期出现前至少1周，用髓磷脂碱性蛋白免疫的小鼠小脑的血脑屏障（BBB）会显著但短暂地受损。在免疫后的第一周用依赖过氧亚硝酸盐的自由基清除剂尿酸（UA）治疗小鼠，可阻断小脑血脑屏障通透性的早期增加以及EAE临床症状的后续发展。这些结果表明，小脑血脑屏障完整性的早期丧失可能是麻痹性EAE发展的必要步骤。
相似文献
1
Early blood-brain barrier permeability in cerebella of PLSJL mice immunized with myelin basic protein.用髓鞘碱性蛋白免疫的PLSJL小鼠小脑早期血脑屏障通透性
J Neuroimmunol. 2008 May 30;196(1-2):8-15. doi: 10.1016/j.jneuroim.2008.02.004. Epub 2008 Apr 11.
2
ICAM-1 upregulation in the spinal cords of PLSJL mice with experimental allergic encephalomyelitis is dependent upon TNF-alpha production triggered by the loss of blood-brain barrier integrity.实验性变应性脑脊髓炎的PLSJL小鼠脊髓中细胞间黏附分子-1（ICAM-1）的上调依赖于血脑屏障完整性丧失引发的肿瘤坏死因子-α（TNF-α）生成。
J Neuroimmunol. 2004 Oct;155(1-2):32-42. doi: 10.1016/j.jneuroim.2004.05.011.
3
The peroxynitrite scavenger uric acid prevents inflammatory cell invasion into the central nervous system in experimental allergic encephalomyelitis through maintenance of blood-central nervous system barrier integrity.过氧亚硝酸盐清除剂尿酸通过维持血-中枢神经系统屏障的完整性，防止炎症细胞侵入实验性变态反应性脑脊髓炎的中枢神经系统。
J Immunol. 2000 Dec 1;165(11):6511-8. doi: 10.4049/jimmunol.165.11.6511.
4
Blood-brain barrier changes and cell invasion differ between therapeutic immune clearance of neurotrophic virus and CNS autoimmunity.神经营养性病毒的治疗性免疫清除与中枢神经系统自身免疫之间，血脑屏障变化和细胞侵袭情况有所不同。
Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15511-6. doi: 10.1073/pnas.0807656105. Epub 2008 Sep 30.
5
Blood-brain barrier disruption and lesion localisation in experimental autoimmune encephalomyelitis with predominant cerebellar and brainstem involvement.在以小脑和脑干受累为主的实验性自身免疫性脑脊髓炎中血脑屏障破坏与病变定位
J Neuroimmunol. 2005 Mar;160(1-2):162-9. doi: 10.1016/j.jneuroim.2004.11.011. Epub 2005 Jan 7.
6
Protection of myelin basic protein immunized mice from free-radical mediated inflammatory cell invasion of the central nervous system by the natural peroxynitrite scavenger uric acid.天然过氧亚硝酸盐清除剂尿酸对髓鞘碱性蛋白免疫小鼠中枢神经系统免受自由基介导的炎性细胞侵袭的保护作用。
Neurosci Lett. 2000 Oct 6;292(2):137-41. doi: 10.1016/s0304-3940(00)01446-4.
7
Cerebellar susceptibility to experimental autoimmune encephalomyelitis in SJL/J mice: potential interaction of immunology with vascular anatomy.SJL/J小鼠小脑对实验性自身免疫性脑脊髓炎的易感性：免疫学与血管解剖学的潜在相互作用。
Cerebellum. 2002 Jan-Mar;1(1):57-68. doi: 10.1080/147342202753203096.
8
Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood-CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis.尿酸作为一种过氧亚硝酸盐清除剂，在多发性硬化症小鼠模型中可抑制中枢神经系统炎症、血脑屏障通透性变化及组织损伤。
FASEB J. 2000 Apr;14(5):691-8. doi: 10.1096/fasebj.14.5.691.
9
Deletion of both ICAM-1 and C3 enhances severity of experimental autoimmune encephalomyelitis compared to C3-deficient mice.与C3缺陷小鼠相比，ICAM - 1和C3双缺失会加重实验性自身免疫性脑脊髓炎的严重程度。
Neurosci Lett. 2008 Sep 12;442(2):158-60. doi: 10.1016/j.neulet.2008.07.005. Epub 2008 Jul 6.
10
Blood-brain barrier breakdown and increased intercellular adhesion molecule (ICAM-1/CD54) expression after Semliki Forest (A7) virus infection facilitates the development of experimental allergic encephalomyelitis.塞姆利基森林（A7）病毒感染后血脑屏障破坏及细胞间黏附分子（ICAM-1/CD54）表达增加促进实验性自身免疫性脑脊髓炎的发展。
J Neuroimmunol. 1996 May;66(1-2):103-14. doi: 10.1016/0165-5728(96)00031-8.
引用本文的文献
1
Modulator of VRAC Current 1 Is a Potential Target Antigen in Multiple Sclerosis.VRAC电流调节因子1是多发性硬化症中的潜在靶抗原。
Neurol Neuroimmunol Neuroinflamm. 2025 Mar;12(2):e200374. doi: 10.1212/NXI.0000000000200374. Epub 2025 Feb 11.
2
Studying the blood-brain barrier will provide new insights into neurodegeneration - Yes.研究血脑屏障将为神经退行性变提供新的见解——没错。
Mult Scler. 2018 Jul;24(8):1023-1024. doi: 10.1177/1352458518754367. Epub 2018 Mar 5.
3
The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS.抗癌剂 SU4312 通过选择性和直接抑制神经元型一氧化氮合酶，出人意料地对 MPP(+)诱导的神经毒性起到保护作用。
Br J Pharmacol. 2013 Mar;168(5):1201-14. doi: 10.1111/bph.12004.
4
The treatment of multiple sclerosis with inosine.用肌苷治疗多发性硬化症。
J Altern Complement Med. 2009 Jun;15(6):619-25. doi: 10.1089/acm.2008.0513.
本文引用的文献
1
CNS-irrelevant T-cells enter the brain, cause blood-brain barrier disruption but no glial pathology.与中枢神经系统无关的T细胞进入大脑，导致血脑屏障破坏，但无神经胶质病理改变。
Eur J Neurosci. 2007 Sep;26(6):1387-98. doi: 10.1111/j.1460-9568.2007.05792.x.
2
Loss of blood-brain barrier integrity in the spinal cord is common to experimental allergic encephalomyelitis in knockout mouse models.在基因敲除小鼠模型中，脊髓血脑屏障完整性的丧失在实验性变应性脑脊髓炎中很常见。
Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5656-61. doi: 10.1073/pnas.0701252104. Epub 2007 Mar 19.
3
Region-specific regulation of inflammation and pathogenesis in experimental autoimmune encephalomyelitis.实验性自身免疫性脑脊髓炎中炎症和发病机制的区域特异性调节
J Neuroimmunol. 2006 Dec;181(1-2):122-32. doi: 10.1016/j.jneuroim.2006.08.012. Epub 2006 Oct 9.
4
Differential susceptibility of cerebral and cerebellar murine brain microvascular endothelial cells to loss of barrier properties in response to inflammatory stimuli.大脑和小脑小鼠脑微血管内皮细胞对炎症刺激引起的屏障特性丧失的易感性差异。
J Neuroimmunol. 2006 Oct;179(1-2):37-45. doi: 10.1016/j.jneuroim.2006.06.019. Epub 2006 Aug 1.
5
Regional differences in blood-brain barrier permeability changes and inflammation in the apathogenic clearance of virus from the central nervous system.血脑屏障通透性变化及炎症在病毒从中枢神经系统无致病性清除过程中的区域差异。
J Immunol. 2006 Jun 15;176(12):7666-75. doi: 10.4049/jimmunol.176.12.7666.
6
Cytokines in multiple sclerosis: from bench to bedside.多发性硬化症中的细胞因子：从实验室到临床
Pharmacol Ther. 2005 May;106(2):163-77. doi: 10.1016/j.pharmthera.2004.11.007. Epub 2005 Jan 11.
7
Blood-brain barrier disruption and lesion localisation in experimental autoimmune encephalomyelitis with predominant cerebellar and brainstem involvement.在以小脑和脑干受累为主的实验性自身免疫性脑脊髓炎中血脑屏障破坏与病变定位
J Neuroimmunol. 2005 Mar;160(1-2):162-9. doi: 10.1016/j.jneuroim.2004.11.011. Epub 2005 Jan 7.
8
ICAM-1 upregulation in the spinal cords of PLSJL mice with experimental allergic encephalomyelitis is dependent upon TNF-alpha production triggered by the loss of blood-brain barrier integrity.实验性变应性脑脊髓炎的PLSJL小鼠脊髓中细胞间黏附分子-1（ICAM-1）的上调依赖于血脑屏障完整性丧失引发的肿瘤坏死因子-α（TNF-α）生成。
J Neuroimmunol. 2004 Oct;155(1-2):32-42. doi: 10.1016/j.jneuroim.2004.05.011.
9
Cerebellar susceptibility to experimental autoimmune encephalomyelitis in SJL/J mice: potential interaction of immunology with vascular anatomy.SJL/J小鼠小脑对实验性自身免疫性脑脊髓炎的易感性：免疫学与血管解剖学的潜在相互作用。
Cerebellum. 2002 Jan-Mar;1(1):57-68. doi: 10.1080/147342202753203096.
10
Pathogenesis of multiple sclerosis: an update on immunology.多发性硬化症的发病机制：免疫学最新进展
Curr Opin Neurol. 2002 Jun;15(3):227-31. doi: 10.1097/00019052-200206000-00001.
Zotero 插件