Spitsin Sergei, Portocarrero Carla, Phares Timothy W, Kean Rhonda B, Brimer Christine M, Koprowski Hilary, Hooper D Craig
Thomas Jefferson University, 1020 Locust St., JAH room 470C, Philadelphia, PA 19107, United States.
J Neuroimmunol. 2008 May 30;196(1-2):8-15. doi: 10.1016/j.jneuroim.2008.02.004. Epub 2008 Apr 11.
The blood-brain barrier (BBB) is dramatically but transiently compromised in the cerebella of myelin basic protein immunized mice at least 1 week prior to the development of the paralytic phase of experimental allergic encephalomyelitis (EAE). Treatment of mice with the peroxynitrite-dependent radical scavenger uric acid (UA) during the first week after immunization blocks the early increase in cerebellar BBB permeability and the subsequent development of clinical signs of EAE. These results indicate that the early loss of BBB integrity in the cerebellum is likely to be a necessary step in the development of paralytic EAE.
在实验性变应性脑脊髓炎（EAE）麻痹期出现前至少1周，用髓磷脂碱性蛋白免疫的小鼠小脑的血脑屏障（BBB）会显著但短暂地受损。在免疫后的第一周用依赖过氧亚硝酸盐的自由基清除剂尿酸（UA）治疗小鼠，可阻断小脑血脑屏障通透性的早期增加以及EAE临床症状的后续发展。这些结果表明，小脑血脑屏障完整性的早期丧失可能是麻痹性EAE发展的必要步骤。
