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本文引用的文献

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Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia.Claudin-5 的表达与剂量相关，是精神分裂症的修饰因子。
Mol Psychiatry. 2018 Nov;23(11):2156-2166. doi: 10.1038/mp.2017.156. Epub 2017 Oct 10.
2
Internalization and presentation of myelin antigens by the brain endothelium guides antigen-specific T cell migration.脑内皮细胞对髓磷脂抗原的内化和呈递引导抗原特异性T细胞迁移。
Elife. 2016 Jun 23;5:e13149. doi: 10.7554/eLife.13149.
3
Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke.免疫细胞在多发性硬化症和中风中穿越中枢神经系统屏障的过程。
Biochim Biophys Acta. 2016 Mar;1862(3):461-71. doi: 10.1016/j.bbadis.2015.10.018. Epub 2015 Oct 23.
4
Amyloid Beta induces oxidative stress-mediated blood-brain barrier changes in capillary amyloid angiopathy.淀粉样β蛋白诱导毛细血管淀粉样血管病中的氧化应激介导的血脑屏障变化。
Antioxid Redox Signal. 2011 Sep 1;15(5):1167-78. doi: 10.1089/ars.2011.3895. Epub 2011 Mar 23.
5
Adenosine triphosphate-binding cassette transporters mediate chemokine (C-C motif) ligand 2 secretion from reactive astrocytes: relevance to multiple sclerosis pathogenesis.三磷酸腺苷结合盒转运蛋白介导反应性星形胶质细胞分泌趋化因子（C-C 基序）配体 2：与多发性硬化发病机制相关。
Brain. 2011 Feb;134(Pt 2):555-70. doi: 10.1093/brain/awq330. Epub 2010 Dec 22.
6
Early blood-brain barrier permeability in cerebella of PLSJL mice immunized with myelin basic protein.用髓鞘碱性蛋白免疫的PLSJL小鼠小脑早期血脑屏障通透性
J Neuroimmunol. 2008 May 30;196(1-2):8-15. doi: 10.1016/j.jneuroim.2008.02.004. Epub 2008 Apr 11.
7
Quantification of subtle blood-brain barrier disruption in non-enhancing lesions in multiple sclerosis: a study of disease and lesion subtypes.多发性硬化症非强化病灶中细微血脑屏障破坏的定量分析：疾病及病灶亚型研究
Mult Scler. 2007 Aug;13(7):884-94. doi: 10.1177/1352458507076970. Epub 2007 Apr 27.
8
Persistent endothelial abnormalities and blood-brain barrier leak in primary and secondary progressive multiple sclerosis.原发性和继发性进展型多发性硬化症中持续存在的内皮异常和血脑屏障渗漏
Neuropathol Appl Neurobiol. 2007 Feb;33(1):86-98. doi: 10.1111/j.1365-2990.2006.00781.x.
9
Blood-brain barrier disruption results in delayed functional and structural alterations in the rat neocortex.血脑屏障破坏导致大鼠新皮质出现延迟性的功能和结构改变。
Neurobiol Dis. 2007 Feb;25(2):367-77. doi: 10.1016/j.nbd.2006.10.006. Epub 2006 Dec 22.
10
Blood-brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis.多发性硬化症尸检MRI中局灶性和弥漫性异常的血脑屏障改变
Neurobiol Dis. 2005 Dec;20(3):953-60. doi: 10.1016/j.nbd.2005.06.012. Epub 2005 Jul 21.

Studying the blood-brain barrier will provide new insights into neurodegeneration - Yes.

作者信息

Kamphuis Wouter W, De Vries Helga E

机构信息

Brendinn Therapeutics, VU University Medical Center, Amsterdam, The Netherlands.

Blood-Brain Barrier Research Group, Department of Molecular Cell Biology and Immunology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.

出版信息

Mult Scler. 2018 Jul;24(8):1023-1024. doi: 10.1177/1352458518754367. Epub 2018 Mar 5.

DOI:10.1177/1352458518754367
PMID:29504448
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6029146/
Abstract
摘要