de las Fuentes Lisa, Gu C Charles, Mathews Santhosh J, Reagan Joann L, Ruthmann Nicholas P, Waggoner Alan D, Lai Chung-Fang, Towler Dwight A, Dávila-Román Víctor G
Cardiovascular Imaging and Clinical Research Core Laboratory, Cardiovascular Division, Washington University School of Medicine, St Louis, MO 63110, USA.
J Am Soc Echocardiogr. 2008 Aug;21(8):954-60. doi: 10.1016/j.echo.2008.02.005. Epub 2008 Apr 11.
Osteopontin (OPN)-transgenic mice exhibit increased carotid artery intima-media thickness (CIMT), smooth muscle cell proliferation, and atheroma formation.
An association of the human T-66G promoter variant with CIMT was examined in Caucasian adults grouped according to metabolic syndrome criteria: present (+MetS; n = 70) or absent (-MetS; n = 70).
The G-allele frequency was 22%. For the entire cohort, the G group (TG and GG) was associated with significantly lower age-adjusted and gender-adjusted CIMT compared with the TT group (P = .008); similar analysis by metabolic syndrome group found a significant difference only in the -MetS group (P = .018). Stepwise multivariate regression showed that after age and waist circumference, the T-66G variant was the next most predictive of CIMT (P = .007). These data suggest that in a normoglycemic environment, human vascular OPN gene expression contributes to arterial structure, an effect diminished in dysmetabolic states.
Humans with the OPN -66 TT genotype, particularly those without metabolic syndrome, exhibit thicker CIMT.
骨桥蛋白（OPN）转基因小鼠表现出颈动脉内膜中层厚度（CIMT）增加、平滑肌细胞增殖和动脉粥样硬化形成。
在根据代谢综合征标准分组的白种成年人中，研究人类T-66G启动子变体与CIMT的关联：存在代谢综合征（+MetS；n = 70）或不存在代谢综合征（-MetS；n = 70）。
G等位基因频率为22%。对于整个队列，与TT组相比，G组（TG和GG）的年龄和性别校正后的CIMT显著更低（P = .008）；按代谢综合征组进行的类似分析仅在-MetS组中发现显著差异（P = .018）。逐步多元回归显示，在年龄和腰围之后，T-66G变体是CIMT的下一个最具预测性的因素（P = .007）。这些数据表明，在血糖正常的环境中，人类血管OPN基因表达有助于动脉结构，而在代谢异常状态下这种作用减弱。
具有OPN -66 TT基因型的人，尤其是那些没有代谢综合征的人，表现出更厚的CIMT。
