CD8(+) 调节性T细胞的新观念
Emerging concepts in CD8(+) T regulatory cells.
作者信息
Niederkorn Jerry Y
机构信息
Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
出版信息
Curr Opin Immunol. 2008 Jun;20(3):327-31. doi: 10.1016/j.coi.2008.02.003. Epub 2008 Apr 10.
Abstract
CD8(+) T regulatory cells (T regs) are elicited by unique antigen presenting cells during viral infections, by manipulation of co-stimulatory molecules, or in the development of tumors. CD8(+) T regs display antigen-specificity, which is most exquisitely manifested by the HLA-E-restricted cytolytic CD8(+) T regs in MS. There is evidence that some CD8(+) T regs also express organ specificity. In many cases, IFN-gamma is required for either the induction or expression of CD8(+) T regs. CD8(+) T regs can produce suppression directly by killing immune cells or indirectly by co-opting other cells to elaborate end-stage suppressive molecules such as TGF-beta, IL-10, and indoleamine dioxygenase (IDO).
摘要
CD8(+)调节性T细胞（Tregs）在病毒感染期间由独特的抗原呈递细胞引发，通过共刺激分子的操控，或在肿瘤发展过程中产生。CD8(+) Tregs表现出抗原特异性，这在多发性硬化症中由HLA-E限制性细胞毒性CD8(+) Tregs最为精妙地体现出来。有证据表明，一些CD8(+) Tregs也表达器官特异性。在许多情况下，CD8(+) Tregs的诱导或表达需要γ干扰素。CD8(+) Tregs可以通过杀死免疫细胞直接产生抑制作用，或通过利用其他细胞来产生终末期抑制分子如转化生长因子-β、白细胞介素-10和吲哚胺双加氧酶（IDO）间接产生抑制作用。
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