GnRH 诱导的促性腺激素细胞中的钙和电流振荡。

GnRH-induced calcium and current oscillations in gonadotrophs.

机构信息

Stanko S. Stojilkovic and Melanija Tomić are at the Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.

出版信息

Trends Endocrinol Metab. 1996 Dec;7(10):379-84. doi: 10.1016/s1043-2760(96)00189-0.

DOI:10.1016/s1043-2760(96)00189-0

PMID:18406776

Abstract

The rat pituitary gonadotroph is a well-studied cell model for investigation of the oscillatory nature of calcium signaling in agonist-stimulated excitable cells. Cytosolic calcium levels (Ca(2+)) in gonadotrophs are controlled by two distinct oscillators, a plasma membrane oscillator that generates extracellular calcium-dependent low-amplitude Ca(2+) spiking in unstimulated cells and an endoplasmic reticulum oscillator that is activated by calcium-mobilizing receptors for GnRH, endothelin, and pituitary adenylate cyclase-activating polypeptide. In this review, the characteristics of the spontaneous and agonist-induced calcium oscillations in gonadotrophs and the coordinate actions of the two oscillators during GnRH action discussed.

摘要

大鼠垂体促性腺细胞是研究激动剂刺激兴奋细胞中钙信号振荡性质的一种成熟的细胞模型。促性腺细胞中的细胞质钙离子浓度 (Ca(2+)) 受两个不同振荡器的控制，一个是质膜振荡器，它在未受刺激的细胞中产生依赖细胞外钙的低幅度 Ca(2+) 尖峰，另一个是内质网振荡器，它由 GnRH、内皮素和垂体腺苷酸环化酶激活肽的钙动员受体激活。在这篇综述中，讨论了促性腺细胞中自发和激动剂诱导的钙振荡的特征，以及在 GnRH 作用期间两个振荡器的协调作用。