Trends Endocrinol Metab. 1997 Jan-Feb;8(1):7-14. doi: 10.1016/s1043-2760(96)00206-8.
A fundamental process in the hormonal regulation of body functions is the conversion of the intercellular signal into an intracellular signal. The first recognized intracellular messengers mediating the actions of hormones were calcium ions (Ca(2+)) and adenosine 3':5' monophosphate (cAMP), which is synthesized from ATP by adenylyl cyclase. Recent work on the structure of adenylyl cyclases has shown that these enzymes are individually tailored molecular machines controlled by diverse Ca(2+)-dependent mechanisms. These include allosteric regulation of enzyme activity through the Ca(2+)-receptor protein calmodulin, apparently direct actions of Ca(2+)on the cyclase catalytic moiety and phosphorylation/dephosphorylation by Ca(2+)-regulated protein kinases and protein phosphatases. This article is a brief review of the recent developments in the area of cyclase control that forecast a major revival of the interest in cAMP-Ca(2+)interactions. (c) 1997, Elsevier Science Inc. (Trends Endocrinol Metab 1997;8:7-14).
在激素调节身体功能的基本过程中，将细胞间信号转换为细胞内信号。第一个被识别的介导激素作用的细胞内信使是钙离子（Ca(2+)) 和三磷酸腺苷（ATP）合成的环磷酸腺苷（cAMP）。最近关于腺苷酸环化酶结构的研究表明，这些酶是通过各种 Ca(2+)-依赖性机制控制的个体化定制的分子机器。这些机制包括通过 Ca(2+)-受体蛋白钙调蛋白对酶活性的变构调节，Ca(2+)对环化酶催化部分的直接作用，以及 Ca(2+)-调节的蛋白激酶和蛋白磷酸酶的磷酸化/去磷酸化。本文简要回顾了环化酶控制领域的最新进展，这些进展预示着人们对 cAMP-Ca(2+)相互作用的兴趣将重新高涨。（c）1997，Elsevier Science Inc.（趋势内分泌代谢 1997；8:7-14）。
