Rescigno J, Mansukhani A, Basilico C
Department of Microbiology, New York University School of Medicine, New York 10016.
Oncogene. 1991 Oct;6(10):1909-13.
We have cloned a murine cDNA on the basis of homology to the tyrosine kinase domain of the bek fibroblast growth factor receptor. This cDNA encodes a putative tyrosine kinase receptor with a unique structural pattern in its extracellular domain. It is a new member of the immunoglobulin superfamily with two immunoglobulin-like domains. It also contains two fibronectin type III domains which are found on diverse proteins such as receptor tyrosine phosphatases and neural cell adhesion molecules. This protein tyrosine kinase called ark (adhesion-related kinase) is likely to represent a new class of receptor tyrosine kinase. Ark mRNA appears to be expressed in most cell lines and adult tissues examined except those of hematopoietic lineage. It is undetectable in undifferentiated teratocarcinoma cells, F9 and N Tera 2.
我们基于与bek成纤维细胞生长因子受体酪氨酸激酶结构域的同源性克隆了一个小鼠cDNA。该cDNA编码一种推定的酪氨酸激酶受体，其细胞外结构域具有独特的结构模式。它是免疫球蛋白超家族的一个新成员，有两个免疫球蛋白样结构域。它还包含两个III型纤连蛋白结构域，这些结构域存在于多种蛋白质上，如受体酪氨酸磷酸酶和神经细胞粘附分子。这种名为ark（粘附相关激酶）的蛋白酪氨酸激酶可能代表了一类新的受体酪氨酸激酶。Ark mRNA似乎在除造血谱系细胞系和组织之外的大多数所检测的细胞系和成年组织中都有表达。在未分化的畸胎瘤细胞F9和NTera 2中未检测到它。
