催乳素变体。

Prolactin variants.

机构信息

Yagya N. Sinha is at the Whittier Institute for Diabetes and Endrocrinology at Scripps Memorial Hospital, La Jolla, CA 92037, USA.

出版信息

Trends Endocrinol Metab. 1992 Apr;3(3):100-6. doi: 10.1016/1043-2760(92)90021-r.

DOI:10.1016/1043-2760(92)90021-r

PMID:18407087

Abstract

Prolactin (PRL) is one of the most versatile hormones of the pituitary in terms of biologic actions, but how a single molecule is able to evoke so many different responses in the organism is not known. Research in recent years has uncovered a surprising degree of structural polymorphism for PRL, the different forms having variable biopotencies. Such findings lend credence to the hypothesis that the molecular heterogeneity of PRL is one of the mechanisms for creating diversity in the biologic actions of this hormone.

摘要

催乳素（PRL）是垂体中生物作用最广泛的激素之一，但目前尚不清楚是什么原因使得一个单一的分子能够在生物体中引发如此多不同的反应。近年来的研究揭示了 PRL 存在惊人程度的结构多态性，不同形式的 PRL 具有不同的生物效价。这些发现为假设提供了依据，即 PRL 的分子异质性是该激素生物作用多样性的机制之一。