皮质抑素。

Corticostatins.

机构信息

Endocrine Laboratory, Royal Victoria Hospital and Departments of Biochemistry, Medicine and Obstetrics and Gynecology, McGill University, Montreal, Quebec H3A IAl, Canada.

出版信息

Trends Endocrinol Metab. 1993 Oct;4(8):260-4. doi: 10.1016/1043-2760(93)90096-w.

DOI:10.1016/1043-2760(93)90096-w

PMID:18407166

Abstract

Corticostatic (anti-ACTH) peptides were first isolated from rabbit fetal and adult lung and from rabbit neutrophils. They have now been isolated from human, rat, and guinea pig tissues. They have several biologic activities that include inhibition of ACTH binding, stimulation of L-type Ca(2+) channels, monocyte chemotaxis, and degranulation of mast cells with the release of histamine. Rabbit corticostatin I (CSI) is widely distributed in maternal and fetal rabbit tissues and is localized to neutrophils, macrophages, and monocytes, and the changing concentration of CSI with advancing gestation indicates a possible physiologic role during pregnancy.

摘要

皮质抑素（抗 ACTH）肽最初从兔胎肺和成年肺以及兔中性粒细胞中分离得到。现在已经从人、大鼠和豚鼠组织中分离出来。它们具有几种生物活性，包括抑制 ACTH 结合、刺激 L 型 Ca(2+)通道、单核细胞趋化性以及释放组胺导致肥大细胞脱颗粒。兔皮质抑素 I（CSI）广泛分布于母兔和胎兔组织中，并定位于中性粒细胞、巨噬细胞和单核细胞，CSI 浓度随妊娠进展而变化表明其在妊娠期间可能具有生理作用。