Quon M J, Butte A J, Taylor S I
Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Trends Endocrinol Metab. 1994 Nov;5(9):369-76. doi: 10.1016/1043-2760(94)90104-x.
Insulin initiates its pleiotropic effects by activating the insulin receptor tyrosine kinase to phosphorylate several intracellular proteins. Recent studies have demonstrated that phosphotyrosine residues bind specifically to proteins that contain src homology 2 (SH2) domains, and that this interaction mediates the regulation of multiple intracellular signaling pathways. This article reviews recent progress in elucidating the detailed pathways that lead from the insulin receptor to the ultimate biologic actions of insulin.
胰岛素通过激活胰岛素受体酪氨酸激酶使几种细胞内蛋白质磷酸化来启动其多效性作用。最近的研究表明，磷酸酪氨酸残基特异性结合含有src同源2（SH2）结构域的蛋白质，并且这种相互作用介导多种细胞内信号通路的调节。本文综述了在阐明从胰岛素受体到胰岛素最终生物学作用的详细途径方面的最新进展。
