Fujiki Minoru, Kubo Takeshi, Kamida Tohru, Sugita Kenji, Hikawa Takamitsu, Abe Tatsuya, Ishii Keisuke, Kobayashi Hidenori
Department of Neurosurgery, School of Medicine, Oita University, Oita, Japan.
J Clin Neurosci. 2008 Jul;15(7):791-6. doi: 10.1016/j.jocn.2007.07.002. Epub 2008 Apr 14.
In this study we evaluated the effect of donepezil on the neurodegeneration and behavioral impairments induced by mild traumatic brain injury (MTBI). Donepezil is an acetylcholinesterase inhibitor that is used to treat Alzheimer's disease. Donepezil was given orally to rats subjected to MTBI. Treatment with a single oral dose of donepezil (12mg/kg) immediately after injury significantly attenuated MTBI-induced neuronal death and cognitive impairment as measured by preservation of neurons in the CA1 region of the hippocampus and a water maze test respectively. However, these neuroprotective effects were prevented by concomitant injection of mecamylamine, a nicotinic acetylcholine-receptor (nAChR) antagonist, indicating that protection is mediated by nAChR activation.
在本研究中，我们评估了多奈哌齐对轻度创伤性脑损伤（MTBI）所致神经退行性变和行为障碍的影响。多奈哌齐是一种用于治疗阿尔茨海默病的乙酰胆碱酯酶抑制剂。对遭受MTBI的大鼠口服多奈哌齐。损伤后立即单次口服给予多奈哌齐（12mg/kg），分别通过海马CA1区神经元的保存情况和水迷宫试验测量，显著减轻了MTBI诱导的神经元死亡和认知障碍。然而，同时注射烟碱型乙酰胆碱受体（nAChR）拮抗剂美加明可阻止这些神经保护作用，表明这种保护是由nAChR激活介导的。
