Bisdas Sotirios, Baghi Mehran, Wagenblast Jens, Vogl Thomas J, Thng Choon Hua, Koh Tong San
Department of Diagnostic and Interventional Radiology, Johann Wolfgang Goethe University Hospital, Frankfurt, Germany.
J Magn Reson Imaging. 2008 May;27(5):963-9. doi: 10.1002/jmri.21311.
To examine the feasibility of first-pass dynamic contrast-enhanced (DCE) T2-weighted MRI of tumors in the extracranial head and neck by applying a distributed-parameter (DP) tracer kinetic model to quantify the perfusion parameters.
A total of 16 patients with primary malignant and benign tumors in the head and neck underwent DCE-MR studies. A spin-echo (SE) echo-planar-imaging (EPI) MR-sequence was applied for first-pass DCE-T2-weighted imaging. The data were postprocessed applying a DP tracer kinetic model that accounts for capillary-tissue exchange. Region-of-interest (ROI) analysis was performed in the tumor sites and the adjacent normal tissue. Blood flow (F), intravascular blood volume (v(1)), extravascular extracellular volume (v(2)), difference in bolus arrival time between arterial input and tissue (t(0)), intravascular mean transit time (t(1)), permeability (PS), and extraction ratio (E) maps were generated for each patient.
All perfusion values in the tumor sites were significantly different (0.000 < or = P < or = 0.01) than those in the normal muscle tissue. The median perfusion values in the tumor tissue were: F = 150.5 mL/minute/100 g, v(1) = 11.0 mL/100 g, v(2) = 31.5 mL/100 g, t(0) = 4.5 seconds, t(1) = 8.0 seconds, PS = 96.0 mL/minute/100 g, and E = 32.5.
EPI-T2-weighted DCE-MR in head and neck tumors as well as quantification of the perfusion values using DP model physiologic imaging was feasible and the promising initial results have encourages further validation studies in the future.
通过应用分布式参数（DP）示踪剂动力学模型来量化灌注参数，研究颅外头颈部肿瘤的首过动态对比增强（DCE）T2加权磁共振成像（MRI）的可行性。
16例头颈部原发性恶性和良性肿瘤患者接受了DCE-MR研究。采用自旋回波（SE）回波平面成像（EPI）MR序列进行首过DCE-T2加权成像。应用考虑毛细血管-组织交换的DP示踪剂动力学模型对数据进行后处理。在肿瘤部位和相邻正常组织进行感兴趣区（ROI）分析。为每位患者生成血流（F）、血管内血容量（v(1)）、血管外细胞外容量（v(2)）、动脉输入与组织之间的团注到达时间差（t(0)）、血管内平均通过时间（t(1)）、通透性（PS）和提取率（E）图。
肿瘤部位的所有灌注值与正常肌肉组织的灌注值均有显著差异（0.000≤P≤0.01）。肿瘤组织中的灌注值中位数为：F = 150.5 mL/分钟/100 g，v(1) = 11.0 mL/100 g，v(2) = 31.5 mL/100 g，t(0) = 4.5秒，t(1) = 8.0秒，PS = 96.0 mL/分钟/100 g，E = 32.5。
头颈部肿瘤的EPI-T2加权DCE-MR以及使用DP模型生理成像对灌注值进行量化是可行的，这些有前景的初步结果鼓励未来进行进一步的验证研究。
