Tang Qiang, Zhang Chao, Luo Meiming
Key Laboratory of Green Chemistry and Technology of Ministry of Education at Sichuan University, College of Chemistry, Sichuan University, Chengdu 610064, PR China.
J Am Chem Soc. 2008 May 7;130(18):5840-1. doi: 10.1021/ja711153b. Epub 2008 Apr 12.
An unexpected reaction of N,N-disubstituted hydrazine with naphthol and its analogues under simply thermal conditions has been disclosed. 2-Naphthol reacted with various N,N-disubstituted hydrazines under argon to afford 1-amino-2-naphthol and the corresponding secondary amines in excellent yields. Ortho amination of 2-naphthols, hydroxyquinoline, and naphthalenamine occurred when they reacted with N-methyl-N-phenylhydrazine.
已揭示了N，N-二取代肼在简单热条件下与萘酚及其类似物发生的意外反应。在氩气氛围下，2-萘酚与各种N，N-二取代肼反应，以优异的产率得到1-氨基-2-萘酚和相应的仲胺。当2-萘酚、羟基喹啉和萘胺与N-甲基-N-苯基肼反应时，会发生邻位胺化反应。
