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[动脉高血压的心理生理标志物]

[Psychophysiologic markers of arterial hypertension].

作者信息

Nazzaro P, Manzari M, Merlo M, Pirrelli A

机构信息

Centro universitario studio dello stress, Università di Bari.

出版信息

Boll Soc Ital Biol Sper. 1991 Dec;67(12):999-1006.

PMID:1840802
Abstract

Many studies, concerning cardiovascular reactivity in hypertensives, show contrasting data. The aim of the present study was to check, also measuring extracardiovascular variables, a procedure able to identify a peculiar characteristic of the prehypertensive phase. We studied 47 normotensives, who referred high blood pressure values, but that we did not find in our visit. The cardioneurovascular assessment was evaluated, by means of a non invasive, beat to beat technique, measuring SBP, DBP, HR, muscular contraction and skin conductance level (EMG, SCL), peripheric temperature (PT), during a psychophysiologic session. This was composed by 4 stressors (mental arithmetic and Sacks test, acoustic and electric stimulations), 5 minutes each, preceded and followed by an observation period of 10 minutes. After 18 month follow-up, we could distinguish 26 hypertensives (H), and 21 subjects maintained normal blood pressure values (N). The obtained findings showed, with statistical significance, 1) the hyperresponsiveness of SCL and PT; 2) the failed recovery, with consequent hyperdysreactivity, of SCL and PT; 3) the presence of both these phenomena in the H., while SBP, DBP and HR responses did not result a discriminative tool. These data seem 1) to reinforce the hypothesis that a hypersympathetic phase can characterize the prehypertensive stages of essential hypertension and 2) to suggest the psychophysiological approach as a useful method to diagnose prehypertension.

摘要

许多关于高血压患者心血管反应性的研究得出了相互矛盾的数据。本研究的目的是通过测量心血管外变量来检验一种能够识别高血压前期特殊特征的程序。我们研究了47名血压正常但自称血压值高的人,不过在我们的检查中未发现高血压。在一次心理生理测试期间,通过一种非侵入性的逐搏技术评估心脏神经血管功能,测量收缩压、舒张压、心率、肌肉收缩和皮肤电导率水平(肌电图、皮肤电导率)以及外周温度。该测试由4种应激源(心算和萨克斯测试、声音和电刺激)组成,每种应激源持续5分钟,前后各有10分钟的观察期。经过18个月的随访,我们区分出26名高血压患者(H组)和21名血压维持正常的受试者(N组)。所得结果具有统计学意义,表明:1)皮肤电导率和外周温度反应过度;2)皮肤电导率和外周温度未能恢复,从而出现反应过度;3)这些现象在高血压患者中均存在,而收缩压、舒张压和心率反应并非鉴别工具。这些数据似乎:1)强化了这样一种假设,即交感神经过度活跃阶段可能是原发性高血压前期的特征;2)表明心理生理学方法是诊断高血压前期的一种有用方法。

相似文献

1
[Psychophysiologic markers of arterial hypertension].[动脉高血压的心理生理标志物]
Boll Soc Ital Biol Sper. 1991 Dec;67(12):999-1006.
2
Borderline hypertension: relationship between job and psychophysiological profile.临界高血压:工作与心理生理特征之间的关系。
Boll Soc Ital Biol Sper. 1992 May;68(5):293-300.
3
[Hemodynamic and psychophysiologic evaluation in hypertensive diabetic patients].[高血压糖尿病患者的血流动力学和心理生理学评估]
Boll Soc Ital Biol Sper. 1991 Dec;67(12):1007-14.
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[Left ventricular hypertrophy: physiopathological signs using a hemodynamic and cardio-autonomic approach].[左心室肥厚:采用血液动力学和心脏自主神经方法的生理病理体征]
Boll Soc Ital Biol Sper. 1992 Apr;68(4):231-8.
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Cardiovascular reactivity in patients with essential or renal hypertension under standardized mental stress.
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Borderline hypertension. Circulatory, sympatho-adrenal and psychological reactions to stress.临界高血压。对压力的循环、交感 - 肾上腺及心理反应。
Acta Med Scand Suppl. 1985;692:1-90.
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Psychophysiological interrelations and reactivity characteristics in hypertensives.
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Stress reactivity in responder and non-responder hypertensives treated with verapamil and enalapril.使用维拉帕米和依那普利治疗的反应性和无反应性高血压患者的应激反应性。
Riv Eur Sci Med Farmacol. 1995 Jul-Aug;17(4):105-13.
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[Response of arterial pressure to mental stress in young patients with high or mild arterial hypertension. Does it reflect the changes in arterial pressure observed during its ambulatory monitoring?].[青年高血压或轻度高血压患者动脉压对精神应激的反应。它是否反映了动态血压监测期间观察到的动脉压变化?]
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Diabetes modifies cardiovascular reactivity during hypertension.糖尿病会改变高血压期间的心血管反应性。
Am J Med Sci. 1994 Feb;307 Suppl 1:S142-5.

引用本文的文献

1
Stress response and antihypertensive treatment.应激反应与降压治疗
Drugs. 1993;46 Suppl 2:133-40; discussion 141. doi: 10.2165/00003495-199300462-00022.