Dinshaw Ketayun, Mishra Gauravi, Shastri Surendra, Badwe Rajendra, Kerkar Rajendra, Ramani Subhash, Thakur Meenakshi, Uplap Pallavi, Kakade Anagha, Gupta Subhadra, Ganesh Balasubramanian
Tata Memorial Hospital, Mumbai, India.
Oncology. 2007;73(3-4):145-53. doi: 10.1159/000126497. Epub 2008 Apr 11.
This study aims to investigate the efficacy of screening by low-cost technology in down-staging and reducing mortality due to breast and cervix cancer.
The present trial is a community-based, cluster randomised controlled cohort study on screening for breast and cervix cancers (clinical breast examination and visual inspection of the cervix after application of 4% acetic acid). Univariate and multivariate logistic regression analyses are conducted to identify the predictors of participation in screening.
The average compliance is 71.43 and 64.93% for breast and cervix cancer screening, respectively, with the highest compliance in round 1. At the end of 3 screening rounds, 94 and 84% of the eligible women were screened at least once for breast and cervix cancer, respectively. Younger women, women from other than Hindu and Muslim communities, school level-educated women, women belonging to lower-income families, Marathi-speaking women, married women and women who had previously consulted for any breast or gynaecological complaints had higher compliance to participation in screening.
Good compliance rates to screening have been demonstrated in the trial, reflecting acceptance of the study by the society, which has implications while translating the trial into a programme.
本研究旨在调查采用低成本技术进行筛查在降低乳腺癌和宫颈癌分期及死亡率方面的效果。
本试验是一项基于社区的整群随机对照队列研究，针对乳腺癌和宫颈癌进行筛查（临床乳腺检查以及应用4%醋酸后对宫颈进行视诊）。进行单因素和多因素逻辑回归分析以确定参与筛查的预测因素。
乳腺癌和宫颈癌筛查的平均依从率分别为71.43%和64.93%，第一轮的依从率最高。在三轮筛查结束时，分别有94%和84%的符合条件的女性至少接受过一次乳腺癌和宫颈癌筛查。年轻女性、非印度教和穆斯林社区的女性、受过学校教育的女性、低收入家庭的女性、说马拉地语的女性、已婚女性以及之前因任何乳腺或妇科问题咨询过的女性参与筛查的依从性更高。
试验中已证明筛查的依从率良好，这反映出社会对该研究的接受度，这在将试验转化为项目时具有重要意义。
