Sears Jessica, Patel N C
Pediatric Neurology, Department of Child Health, University of Missouri-Columbia, Columbia, MO 65212, USA.
CNS Spectr. 2008 Apr;13(4):301-3. doi: 10.1017/s1092852900016412.
Tics and Tourette syndrome are common comorbidities of patients diagnosed with attention-deficit/hyperactivity disorder (ADHD). One of the mainstay pharmacologic therapies for ADHD has been stimulants. However, this class of drugs has been associated with tic exacerbations, thus limiting their utility in this patients subgroup. Atomoxetine has been explored as an alternative treatment as one of the few non-stimulants available to treat ADHD. Early data identifies atomoxetine's influence on Tourette symptomatology to be not merely equivocal but potentially suppressive in the manifestation of tics. There are, however, case studies describing patients experiencing recurrences of tics following treatment with atomoxetine. We present a unique case of a patient, without any prior history of a movement disorder, who developed tics following a single dose of atomoxetine that did not improve until interventional therapy was initiated.
抽动和妥瑞氏综合征是被诊断患有注意力缺陷多动障碍（ADHD）患者的常见共病。治疗ADHD的主要药物疗法之一是使用兴奋剂。然而，这类药物与抽动症状加重有关，因此限制了它们在该患者亚组中的应用。托莫西汀作为少数可用于治疗ADHD的非兴奋剂之一，已被探索作为一种替代治疗方法。早期数据表明，托莫西汀对妥瑞氏症状的影响不仅不明确，而且在抽动表现方面可能具有抑制作用。然而，有案例研究描述了患者在使用托莫西汀治疗后出现抽动复发的情况。我们报告了一个独特的病例，该患者此前没有任何运动障碍病史，在服用单剂量托莫西汀后出现抽动，直到开始介入治疗才有所改善。
