Schulze R, Behr W, Wittwer H, Harwix S, Murmann K, V Scheidt W, Ehret W, Schlimok G
II. Medizinische Klinik, Klinikum Augsburg, Stenglinstrasse 2, 86156, Augsburg, Deutschland.
Internist (Berl). 2008 May;49(5):618, 620, 621-22. doi: 10.1007/s00108-008-2119-7.
Painful pink or magenta colored skin lesions characterized by a clear line of demarcation between the affected area and surrounding tissue appearing under therapy with coumarins may be a sign for evolving coumarin-necrosis. Immediate treatment with a protein C preparation in patients with protein C deficiency can prevent necrosis.
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