[II型蛋白S缺乏症中的复发性香豆素坏死]

[Recurrent coumarin necrosis in type II protein S deficiency].

作者信息

Seyfarth H J, Siegemund A, Helling L, Woinke M, Pfeiffer D, Rühlmann C

机构信息

Medizinische Klinik und Poliklinik I, Universität Leipzig und Innere Abteilung des evangelisch-lutherischen Diakonissenkrankenhauses zu Leipzig.

出版信息

Vasa. 2001 Feb;30(1):72-5. doi: 10.1024/0301-1526.30.1.72.

DOI:10.1024/0301-1526.30.1.72

PMID:11284095

Abstract

Coumarin necrosis is a rare but clinical very important complication of therapy with coumarin derivatives. We report a patient with congenital protein S deficiency type II, who developed coumarin necrosis during stabilization of phenprocoumon. Diagnostic problems and therapeutic alternatives are discussed considering the recent literature.

摘要

香豆素坏死是香豆素衍生物治疗中一种罕见但临床意义重大的并发症。我们报告了一例II型先天性蛋白S缺乏症患者，该患者在苯丙香豆素稳定治疗期间发生了香豆素坏死。结合近期文献对诊断问题和治疗选择进行了讨论。