盘基网柄菌细胞骨架的分子遗传学研究方法
Molecular genetic approaches to the cytoskeleton in Dictyostelium.
作者信息
Patterson B, Ruppel K M, Spudich J A
机构信息
Department of Cell Biology, Stanford University, CA 94305.
出版信息
Curr Opin Genet Dev. 1991 Oct;1(3):378-82. doi: 10.1016/s0959-437x(05)80303-x.
PMID:1840895
Abstract
Recent advances in molecular genetic techniques are being applied in Dictyostelium to test and expand prevailing views on the functioning of the actin-based cytoskeleton. Current research involves the disruption, by homologous recombination, of genes encoding cytoskeletal elements. We suggest combining classical and molecular genetic approaches to supplement these investigations.
摘要
分子遗传技术的最新进展正被应用于盘基网柄菌，以检验和拓展关于基于肌动蛋白的细胞骨架功能的主流观点。当前的研究涉及通过同源重组破坏编码细胞骨架元件的基因。我们建议将经典遗传学方法和分子遗传学方法结合起来，以补充这些研究。
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