Welch M D, Holtzman D A, Drubin D G
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
Curr Opin Cell Biol. 1994 Feb;6(1):110-9. doi: 10.1016/0955-0674(94)90124-4.
Budding and fission yeast present significant advantages for studies of the actin cytoskeleton. The application of classical and molecular genetic techniques provides a facile route for the analysis of structure/function relationships, for the isolation of novel proteins involved in cytoskeletal function, and for deciphering the signals that regulate actin assembly in vivo. This review focuses on the budding yeast Saccharomyces cerevisiae and also identifies some recent advances from studies on the fission yeast Schizosaccharomyces pombe, for which studies on the actin cytoskeleton are still in their infancy.
芽殖酵母和裂殖酵母在肌动蛋白细胞骨架研究中具有显著优势。经典和分子遗传学技术的应用为分析结构/功能关系、分离参与细胞骨架功能的新蛋白质以及解读体内调节肌动蛋白组装的信号提供了便捷途径。本综述聚焦于芽殖酵母酿酒酵母,同时也指出了裂殖酵母粟酒裂殖酵母研究中的一些最新进展,其肌动蛋白细胞骨架研究仍处于起步阶段。